- 专利标题: Acceleration sensitive indicator
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申请号: EP14166982.0申请日: 2014-05-05
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公开(公告)号: EP2810717B1公开(公告)日: 2018-10-17
- 发明人: Burghardt, Geza , Glauser, Michael , Gutmann, Oliver , Müller, Daniel , Oosterbroek, Rijk Edwin , Sandoz, Roger , Sarofim, Emad , Savatic, Goran
- 申请人: F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F. Hoffmann-La Roche AG,Roche Diagnostics GmbH
- 当前专利权人: F. Hoffmann-La Roche AG,Roche Diagnostics GmbH
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Curcio, Mario
- 优先权: EP13170918 20130606
- 主分类号: B01L3/14
- IPC分类号: B01L3/14 ; B01L3/00
摘要:
An acceleration sensitive indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) for indicating a centrifugation status of a biological sample, a sample container (100, 100') comprising the acceleration sensitive indicator, a centrifuge (200) for centrifuging sample containers (100, 100') and an analytical system (300) for analyzing centrifuged samples are disclosed. The indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) comprises at least one closed chamber (2, 2', 32, 32', 112) formed between two opposite surfaces. The chamber (2, 2', 32, 32', 112) comprises at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134) comprising at least two fluid transfer zones (4, 4', 5, 5', 16, 17, 18) or at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135). The at least one fluid transfer zone (4, 4', 5, 5', 16, 17, 18) comprises at least one solid carrier phase (14) and at least one fluid (15, 15') stabilized in the solid carrier phase (14), or at least one non-stabilized non-Newtonian fluid (13) having thixotropic and/or shear thinning properties. The at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135) comprises at least one particle stabilizing fluid (35, 83) comprising stabilized dispersed particles (36, 84, 85, 86, 87). In particular, the at least one fluid (13, 15, 15') or particles (36, 84, 85, 86, 87) have a distribution with respect to the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), which is changeable only upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.
公开/授权文献
- EP2810717A1 Acceleration sensitive indicator 公开/授权日:2014-12-10
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