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    Devices and process for separating plasma from a blood sample
    2.
    发明公开
    Devices and process for separating plasma from a blood sample 审中-公开
    装置和方法用于从血液样品中分离血浆

    公开(公告)号：EP2375249A3

    公开(公告)日：2016-12-14

    申请号：EP11160450.0

    申请日：2011-03-30

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Heinrich, Michael ,  Sandoz, Roger ,  Wahl, Hans-Peter ,  Sarofim, Emad ,  Gruebl, Tomas

    IPC分类号： G01N33/49 ,  B01L3/00

    摘要： The present invention pertains to a device for separating plasma from a blood sample comprising a stacked structure which is provided with a first portion including a separating member having a first surface for applying or receiving the blood sample, wherein the separating member is adapted to permit the passage of plasma but to inhibit the passage of cells, and a second portion including an absorptive member for absorbing the plasma, which has a second surface in contact with the separating member for receiving the plasma, wherein the absorptive member is adapted to generate a capillary pressure so as to draw plasma from the separating member to the absorptive member. The first portion is fixed to the backing member in a manner to be removed without destroying the absorptive member. The absorptive member is fixed to the backing member in a manner to be removed without destroying the absorptive member. It further relates to a device wherein the first portion is fixed to the absorptive member in a manner to be removed without destroying the absorptive member. It further relates to a process for separating plasma from a blood sample comprising the following steps of: applying the blood sample to a plasma separating member; drawing said blood sample through said separating member to a plasma absorbing member backed by a backing member; non-destructively removing said absorptive member from said separating member and non-destructively removing said absorptive member from said backing member.

    Vorrichtung und Verfahren zum Einstellen einer Temperatur einer Flüssigkeit
    3.
    发明公开
    Vorrichtung und Verfahren zum Einstellen einer Temperatur einer Flüssigkeit 审中-公开
    Vorrichtung und Verfahren zum Einstellen einer Temperatur einerFlüssigkeit

    公开(公告)号：EP1642647A1

    公开(公告)日：2006-04-05

    申请号：EP04023309.0

    申请日：2004-09-30

    申请人： Roche Diagnostics GmbH ,  F. HOFFMANN-LA ROCHE AG

    发明人： Sandoz, Roger ,  Schubert, Frank Ulrich ,  Bachmann, Hans-Rudolf ,  Baumann, Renato

    IPC分类号： B01L7/00

    CPC分类号： B01L7/00 ,  B01L2200/147 ,  B01L2300/1861

    摘要： Eine Vorrichtung und ein Verfahren zum Einstellen einer Temperatur einer Flüssigkeit, die in einem Probengefäss (11, ..., 18) enthalten ist, sind angegeben, wobei eine Steuereinheit (1) und eine Temperiereinheit (2) vorgesehen sind, die auf die im Probengefäss (11, ..., 18) enthaltene Flüssigkeit wirkt. Des Weiteren ist die Steuereinheit (1) mit der Temperiereinheit (2) wirkverbunden. Die Erfindung zeichnet sich dadurch aus, dass die zu untersuchende Flüssigkeit Absorptionselemente enthält, um die Temperatureinstellung in der zu untersuchenden Flüssigkeit zu beschleunigen. Durch die erfindungsgemässe Vorrichtung wird eine rasche Temperatureinstellung in der zu untersuchenden Flüssigkeit erhalten. Damit kann der Durchsatz von Proben pro Zeiteinheit entsprechend gesteigert werden.

    摘要翻译： 一种用于控制样品容器（11,18）中的液体（I）的温度的装置，包括连接到作用在样品容器中的液体上的加热单元（2）的控制单元（1），其中 液体还含有吸收元件（II），以加速所需的温度调节。 还包括一个独立的权利要求，用于通过向液体中添加（II）来控制上述液体（I）的温度的方法，然后照射样品容器，使得至少一些辐射能量在 II）。

    Acceleration sensitive indicator
    6.
    发明公开
    Acceleration sensitive indicator 审中-公开
    Beschleunigungsempfindliches Anzeigeelement

    公开(公告)号：EP2810717A1

    公开(公告)日：2014-12-10

    申请号：EP14166982.0

    申请日：2014-05-05

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Burghardt, Geza ,  Glauser, Michael ,  Gutmann, Oliver ,  Müller, Daniel ,  Oosterbroek, Rijk Edwin ,  Sandoz, Roger ,  Sarofim, Emad ,  Savatic, Goran

    IPC分类号： B01L3/14 ,  B01L3/00

    CPC分类号： G01P15/02 ,  B01L3/5021 ,  B01L3/5453 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2400/0409

    摘要： An acceleration sensitive indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) for indicating a centrifugation status of a biological sample, a sample container (100, 100') comprising the acceleration sensitive indicator, a centrifuge (200) for centrifuging sample containers (100, 100') and an analytical system (300) for analyzing centrifuged samples are disclosed. The indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) comprises at least one closed chamber (2, 2', 32, 32', 112) formed between two opposite surfaces. The chamber (2, 2', 32, 32', 112) comprises at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134) comprising at least two fluid transfer zones (4, 4', 5, 5', 16, 17, 18) or at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135). The at least one fluid transfer zone (4, 4', 5, 5', 16, 17, 18) comprises at least one solid carrier phase (14) and at least one fluid (15, 15') stabilized in the solid carrier phase (14), or at least one non-stabilized non-Newtonian fluid (13) having thixotropic and/or shear thinning properties. The at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135) comprises at least one particle stabilizing fluid (35, 83) comprising stabilized dispersed particles (36, 84, 85, 86, 87). In particular, the at least one fluid (13, 15, 15') or particles (36, 84, 85, 86, 87) have a distribution with respect to the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), which is changeable only upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

    摘要翻译： 用于指示生物样品的离心状态的加速度敏感指示器（1,1'，1“，31,31'，51,61,71,81,121,121'，131），样品容器（100,100 公开了一种用于离心样品容器（100,100'）的离心机（200）和用于分析离心样品的分析系统（300），包括加速度敏感指示器，指示器（1,1'，1“，31， 31'，51,61,71,81,121,121'，131）包括形成在两个相对表面之间的至少一个封闭腔室（2,2'，32,32'，112）。 所述腔室（2,2'，32,32'，112）包括至少一个指示区域（3,3'，3“，33,53,63,73,93,123,124,124'，133,134 ），所述至少一个指示区（3,3'，3“，33,53,63,73,93,123,124,124'，133,134）包括至少两个流体转移区（4,4'，133） ，5,5'，16,17,18）或至少一个颗粒转移区（34,54,74,75,76,77,82,122,125,125'，135）。 至少一个流体转移区域（4,4'，5,5'，16,17,18）包括至少一个固体载体相（14）和至少一个在固体载体中稳定的流体（15,15'） 相（14）或具有触变性和/或剪切稀化性质的至少一种非稳定的非牛顿流体（13）。 所述至少一个颗粒转移区（34,54,74,75,76,77,82,122,125,125'，135）包括至少一个颗粒稳定流体（35,83），其包含稳定的分散颗粒（36， 84，85，86，87）。 特别地，至少一个流体（13,15,15'）或颗粒（36,84,85,86,87）具有相对于至少一个指示区域（3,3'，3“，3”，“ 33，53，63，73，93，123，124，124'，133,134），其仅在施加高于阈值的g力时可变化，表示离心状态的分布变化。

    Devices and process for separating plasma from a blood sample
    7.
    发明公开
    Devices and process for separating plasma from a blood sample 审中-公开
    Vorrichtungen und Verfahren zum Trennen von Plasma aus einer Blutprobe

    公开(公告)号：EP2375249A2

    公开(公告)日：2011-10-12

    申请号：EP11160450.0

    申请日：2011-03-30

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Heinrich, Michael ,  Sandoz, Roger ,  Wahl, Hans-Peter ,  Sarofim, Emad ,  Gruebl, Tomas

    IPC分类号： G01N33/49 ,  B01L3/00

    摘要： The present invention pertains to a device for separating plasma from a blood sample comprising a stacked structure which is provided with a first portion including a separating member having a first surface for applying or receiving the blood sample, wherein the separating member is adapted to permit the passage of plasma but to inhibit the passage of cells, and a second portion including an absorptive member for absorbing the plasma, which has a second surface in contact with the separating member for receiving the plasma, wherein the absorptive member is adapted to generate a capillary pressure so as to draw plasma from the separating member to the absorptive member. The first portion is fixed to the backing member in a manner to be removed without destroying the absorptive member. The absorptive member is fixed to the backing member in a manner to be removed without destroying the absorptive member. It further relates to a device wherein the first portion is fixed to the absorptive member in a manner to be removed without destroying the absorptive member. It further relates to a process for separating plasma from a blood sample comprising the following steps of: applying the blood sample to a plasma separating member; drawing said blood sample through said separating member to a plasma absorbing member backed by a backing member; non-destructively removing said absorptive member from said separating member and non-destructively removing said absorptive member from said backing member.

    摘要翻译： 本发明涉及一种用于从血液样品分离血浆的装置，包括堆叠结构，该层叠结构设置有第一部分，该第一部分包括具有用于施加或接收血液样本的第一表面的分离部件，其中分离部件适于允许 通过等离子体但是抑制细胞通过的第二部分，以及包括用于吸收等离子体的吸收部件的第二部分，其具有与用于接收等离子体的分离部件接触的第二表面，其中吸收部件适于产生毛细管 压力以将等离子体从分离构件吸入吸收构件。 第一部分以不被破坏吸收构件的方式被移除到固定到背衬构件上。 吸收构件以不会破坏吸收构件的方式被移除而固定到背衬构件上。 本发明还涉及一种装置，其中第一部分以不被破坏吸收构件的方式被移除到吸收构件上。 本发明还涉及一种用于从血液样品中分离血浆的方法，包括以下步骤：将血液样品施加到等离子体分离构件; 将所述血液样品通过所述分离构件拉制成由背衬构件支撑的等离子体吸收构件; 从所述分离构件非破坏性地去除所述吸收构件，并且非破坏性地从所述背衬构件去除所述吸收构件。

    Acceleration sensitive indicator
    8.
    发明授权
    Acceleration sensitive indicator 有权

    公开(公告)号：EP2810717B1

    公开(公告)日：2018-10-17

    申请号：EP14166982.0

    申请日：2014-05-05

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Burghardt, Geza ,  Glauser, Michael ,  Gutmann, Oliver ,  Müller, Daniel ,  Oosterbroek, Rijk Edwin ,  Sandoz, Roger ,  Sarofim, Emad ,  Savatic, Goran

    IPC分类号： B01L3/14 ,  B01L3/00

    CPC分类号： G01P15/02 ,  B01L3/5021 ,  B01L3/5453 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2400/0409

    摘要： An acceleration sensitive indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) for indicating a centrifugation status of a biological sample, a sample container (100, 100') comprising the acceleration sensitive indicator, a centrifuge (200) for centrifuging sample containers (100, 100') and an analytical system (300) for analyzing centrifuged samples are disclosed. The indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) comprises at least one closed chamber (2, 2', 32, 32', 112) formed between two opposite surfaces. The chamber (2, 2', 32, 32', 112) comprises at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134) comprising at least two fluid transfer zones (4, 4', 5, 5', 16, 17, 18) or at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135). The at least one fluid transfer zone (4, 4', 5, 5', 16, 17, 18) comprises at least one solid carrier phase (14) and at least one fluid (15, 15') stabilized in the solid carrier phase (14), or at least one non-stabilized non-Newtonian fluid (13) having thixotropic and/or shear thinning properties. The at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135) comprises at least one particle stabilizing fluid (35, 83) comprising stabilized dispersed particles (36, 84, 85, 86, 87). In particular, the at least one fluid (13, 15, 15') or particles (36, 84, 85, 86, 87) have a distribution with respect to the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), which is changeable only upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.