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    Photometric in plane detection using a rotatable disc
    1.
    发明公开
    Photometric in plane detection using a rotatable disc 审中-公开
    在eeene einer drebbaren Scheibe的Photometrische detektion

    公开(公告)号：EP1752758A1

    公开(公告)日：2007-02-14

    申请号：EP05017277.4

    申请日：2005-08-09

    申请人： Roche Diagnostics GmbH ,  F. HOFFMANN-LA ROCHE AG

    发明人： Griss, Patrick ,  Hein, Heinz-Michael ,  Jaeggi, Rainer ,  Savatic, Goran

    IPC分类号： G01N21/07

    CPC分类号： G01N21/0303 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0806 ,  B01L2300/168 ,  G01N35/00069

    摘要： On an analytical device for photometric detection of chemistry and/or fluid samples comprising a rotatable disc like body (1) a plurality of receptables (7) for fluid samples and optical means (9) for guiding light beams through the receptables are arranged. At least part of the optical means (9) are designed and/or arranged such, that at least part of the light beams is deflected and guided through the receptables in an angle to the radially outward direction on the disc like body (1) which means in an angle to the radius, connecting the respective optical means with the rotation axis (9) of the disc like body (1). (fig.1)

    摘要翻译： 在用于测量化学和/或流体样品的用于光学测量的分析装置中，包括可旋转盘状体（1），用于流体样品的多个容器（7）和用于引导光束穿过容器的光学装置（9）。 光学装置（9）的至少一部分被设计和/或布置成使得至少部分光束被偏转并且引导穿过接收器与盘状体（1）上的径向向外的方向成一角度 意指与半径成一定角度，将相应的光学装置与盘状体（1）的旋转轴线（9）相连接。 （图。1）

    Apparatus for performing nucleic acid analysis
    3.
    发明公开
    Apparatus for performing nucleic acid analysis 审中-公开
    Vorrichtung zurDurchführungvonNukleinsäureanalyse

    公开(公告)号：EP1878496A1

    公开(公告)日：2008-01-16

    申请号：EP06014681.8

    申请日：2006-07-14

    申请人： Roche Diagnostics GmbH ,  F. HOFFMANN-LA ROCHE AG

    发明人： Sarofim, Emad ,  Elsenhans, Olivier, Dr. ,  Kopp, Martin, Dr. ,  Wahl, Hans-Peter, Dr. ,  Savatic, Goran ,  Hutter, Roland Christof

    IPC分类号： B01L3/00 ,  C12Q1/68 ,  G01N35/00

    CPC分类号： B01L3/502715 ,  G01N35/0099 ,  G01N2035/00346

    摘要： The embodiments of the present invention are directed to an automatic apparatus (55), which is designed for performing nucleic acid analysis, optionally including sample preparation, with integrated disposable sample holding and processing devices (1), which devices (1) comprise a sample to be analyzed with the apparatus (55). The apparatus (55) comprises workstations (17, 40) for receiving, holding and processing such integrated disposable devices (1), a reagents station (56) for reagents (25), transfer means (36) for performing movements of an actuator, fluid actuation means for processing the sample (32) and reagents in said disposable devices (1), temperature control means (37) for heating or cooling, detection means for measuring a property of the processed samples (32), and control means for controlling the sample (32) preparation, the handling of the disposable devices (1) and the sample analysis performed by the apparatus (55).

    摘要翻译： 本发明的实施例涉及一种自动装置（55），其被设计用于执行核酸分析，任选地包括样品制备，具有集成的一次性样品保持和处理装置（1），所述装置（1）包括样品 用装置（55）进行分析。 装置（55）包括用于接收，保持和处理这种集成的一次性装置（1）的工作站（17,40），用于试剂（25）的试剂台（56），用于执行致动器的运动的传送装置（36） 用于处理所述一次性装置（1）中的样品（32）和试剂的流体致动装置，用于加热或冷却的温度控制装置（37），用于测量经处理样品（32）的性质的检测装置，以及用于控制 样品（32）制备，一次性装置（1）的处理和由装置（55）进行的样品分析。

    Apparatus for retaining magnetic particles within a flow-through cell
    4.
    发明公开
    Apparatus for retaining magnetic particles within a flow-through cell 审中-公开
    Apparat zumZurückhaltenvon Magnetteilchen在einer von einerFlüssigkeitdurchströmteZelle

    公开(公告)号：EP1331035A1

    公开(公告)日：2003-07-30

    申请号：EP02075267.1

    申请日：2002-01-23

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Elsenhans, Olivier ,  Savatic, Goran ,  Gijs, Martin ,  Rida, Amar

    IPC分类号： B03C1/035

    CPC分类号： B03C1/035 ,  B03C1/288

    摘要： Apparatus for retaining magnetic particles within a segment of a flow-through cell during flow of a fluid through the cell. The apparatus comprises (a) an electrical current source (12); (b) an electromagnet (13) having a winding (14) connected to the current source (12) and an air gap (23) between at least one pair of poles (21, 22) each of which has a corrugated outer surface and (c) a flow-through cell (18) which is configured and dimensioned to receive an amount of magnetic particles to be retained within the flow-through cell and to allow flow of a liquid through the flow-through cell. The liquid carries molecules or particles to be captured by means of the magnetic particles. A portion of the flow-through cell (18) is inserted in air gap (23).

    摘要翻译： 用于在流体通过电池的流动期间将磁性颗粒保持在流通池的段内的装置。 该装置包括（a）电流源（12）; （b）具有连接到电流源（12）的绕组（14）和在至少一对极（21,22）之间的气隙（23）的电磁体（13），每个磁极具有波纹状的外表面和 （c）流通池（18），其配置和尺寸设计成接收一定量的待保留在流通池内的磁性颗粒并允许液体流过流通池。 液体携带通过磁性颗粒捕获的分子或颗粒。 流通池（18）的一部分插入气隙（23）中。

    Acceleration sensitive indicator
    5.
    发明授权
    Acceleration sensitive indicator 有权

    公开(公告)号：EP2810717B1

    公开(公告)日：2018-10-17

    申请号：EP14166982.0

    申请日：2014-05-05

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Burghardt, Geza ,  Glauser, Michael ,  Gutmann, Oliver ,  Müller, Daniel ,  Oosterbroek, Rijk Edwin ,  Sandoz, Roger ,  Sarofim, Emad ,  Savatic, Goran

    IPC分类号： B01L3/14 ,  B01L3/00

    CPC分类号： G01P15/02 ,  B01L3/5021 ,  B01L3/5453 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2400/0409

    摘要： An acceleration sensitive indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) for indicating a centrifugation status of a biological sample, a sample container (100, 100') comprising the acceleration sensitive indicator, a centrifuge (200) for centrifuging sample containers (100, 100') and an analytical system (300) for analyzing centrifuged samples are disclosed. The indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) comprises at least one closed chamber (2, 2', 32, 32', 112) formed between two opposite surfaces. The chamber (2, 2', 32, 32', 112) comprises at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134) comprising at least two fluid transfer zones (4, 4', 5, 5', 16, 17, 18) or at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135). The at least one fluid transfer zone (4, 4', 5, 5', 16, 17, 18) comprises at least one solid carrier phase (14) and at least one fluid (15, 15') stabilized in the solid carrier phase (14), or at least one non-stabilized non-Newtonian fluid (13) having thixotropic and/or shear thinning properties. The at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135) comprises at least one particle stabilizing fluid (35, 83) comprising stabilized dispersed particles (36, 84, 85, 86, 87). In particular, the at least one fluid (13, 15, 15') or particles (36, 84, 85, 86, 87) have a distribution with respect to the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), which is changeable only upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

    Acceleration sensitive indicator
    6.
    发明公开
    Acceleration sensitive indicator 审中-公开
    Beschleunigungsempfindliches Anzeigeelement

    公开(公告)号：EP2810717A1

    公开(公告)日：2014-12-10

    申请号：EP14166982.0

    申请日：2014-05-05

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： Burghardt, Geza ,  Glauser, Michael ,  Gutmann, Oliver ,  Müller, Daniel ,  Oosterbroek, Rijk Edwin ,  Sandoz, Roger ,  Sarofim, Emad ,  Savatic, Goran

    IPC分类号： B01L3/14 ,  B01L3/00

    CPC分类号： G01P15/02 ,  B01L3/5021 ,  B01L3/5453 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2400/0409

    摘要： An acceleration sensitive indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) for indicating a centrifugation status of a biological sample, a sample container (100, 100') comprising the acceleration sensitive indicator, a centrifuge (200) for centrifuging sample containers (100, 100') and an analytical system (300) for analyzing centrifuged samples are disclosed. The indicator (1, 1', 1", 31, 31', 51, 61, 71, 81, 121, 121', 131) comprises at least one closed chamber (2, 2', 32, 32', 112) formed between two opposite surfaces. The chamber (2, 2', 32, 32', 112) comprises at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134) comprising at least two fluid transfer zones (4, 4', 5, 5', 16, 17, 18) or at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135). The at least one fluid transfer zone (4, 4', 5, 5', 16, 17, 18) comprises at least one solid carrier phase (14) and at least one fluid (15, 15') stabilized in the solid carrier phase (14), or at least one non-stabilized non-Newtonian fluid (13) having thixotropic and/or shear thinning properties. The at least one particle transfer zone (34, 54, 74, 75, 76, 77, 82, 122, 125, 125', 135) comprises at least one particle stabilizing fluid (35, 83) comprising stabilized dispersed particles (36, 84, 85, 86, 87). In particular, the at least one fluid (13, 15, 15') or particles (36, 84, 85, 86, 87) have a distribution with respect to the at least one indication zone (3, 3', 3", 33, 53, 63, 73, 93, 123, 124, 124', 133, 134), which is changeable only upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

    摘要翻译： 用于指示生物样品的离心状态的加速度敏感指示器（1,1'，1“，31,31'，51,61,71,81,121,121'，131），样品容器（100,100 公开了一种用于离心样品容器（100,100'）的离心机（200）和用于分析离心样品的分析系统（300），包括加速度敏感指示器，指示器（1,1'，1“，31， 31'，51,61,71,81,121,121'，131）包括形成在两个相对表面之间的至少一个封闭腔室（2,2'，32,32'，112）。 所述腔室（2,2'，32,32'，112）包括至少一个指示区域（3,3'，3“，33,53,63,73,93,123,124,124'，133,134 ），所述至少一个指示区（3,3'，3“，33,53,63,73,93,123,124,124'，133,134）包括至少两个流体转移区（4,4'，133） ，5,5'，16,17,18）或至少一个颗粒转移区（34,54,74,75,76,77,82,122,125,125'，135）。 至少一个流体转移区域（4,4'，5,5'，16,17,18）包括至少一个固体载体相（14）和至少一个在固体载体中稳定的流体（15,15'） 相（14）或具有触变性和/或剪切稀化性质的至少一种非稳定的非牛顿流体（13）。 所述至少一个颗粒转移区（34,54,74,75,76,77,82,122,125,125'，135）包括至少一个颗粒稳定流体（35,83），其包含稳定的分散颗粒（36， 84，85，86，87）。 特别地，至少一个流体（13,15,15'）或颗粒（36,84,85,86,87）具有相对于至少一个指示区域（3,3'，3“，3”，“ 33，53，63，73，93，123，124，124'，133,134），其仅在施加高于阈值的g力时可变化，表示离心状态的分布变化。