发明公开
- 专利标题： TRICYCLIC NUCLEIC ACID ANALOGS
- 专利标题（中）： 三环核酸类似物
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申请号： EP13714164.4申请日： 2013-03-20
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公开(公告)号： EP2850092A1公开(公告)日： 2015-03-25
- 发明人: SETH, Punit, P. , SWAYZE, Eric, E. , HANESSIAN, Stephen , SCHROEDER, Benjamin, R. , GIACOMETTI, Robert, D. , MERNER, Bradley, L.
- 申请人： Isis Pharmaceuticals, Inc.
- 申请人地址： 2855 Gazelle Court Carlsbad, CA 92010 US
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： 2855 Gazelle Court Carlsbad, CA 92010 US
- 代理机构： Carpmaels & Ransford LLP
- 优先权： US201261621851P 20120409
- 国际公布： WO2013154798 20131017
- 主分类号： C07H19/06
- IPC分类号： C07H19/06 ; C07H21/00
摘要：
The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms further comprises a fused carbocyclic or heterocyclic ring. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.
公开/授权文献
- EP2850092B1 TRICYCLIC NUCLEIC ACID ANALOGS 公开/授权日：2017-03-01
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