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公开(公告)号:EP2850092A1
公开(公告)日:2015-03-25
申请号:EP13714164.4
申请日:2013-03-20
发明人: SETH, Punit, P. , SWAYZE, Eric, E. , HANESSIAN, Stephen , SCHROEDER, Benjamin, R. , GIACOMETTI, Robert, D. , MERNER, Bradley, L.
摘要: The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms further comprises a fused carbocyclic or heterocyclic ring. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.