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1.发明公开ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS 审中-公开抗菌素4,5-替代氨基糖苷类似物模拟物麻醉剂替代物
公开(公告)号：EP1957507A2
公开(公告)日：2008-08-20
申请号：EP06844751.5
申请日：2006-12-01
发明人： SWAYZE, Eric, E. , HANESSIAN, Stephen , SZYCHOWSKI, Janek , ADHIKARI, Susanta, Sekhar , PACHAMUTHU, Kandasamy , WANG, Xiaojing , MIGAWA, Michael, T. , GRIFFEY, Richard H.
IPC分类号： C07H15/23 , C07H15/232 , A61K31/70
CPC分类号： C07H15/23 , C07H15/232
摘要： The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及氨基糖苷类化合物的类似物以及它们作为抗微生物感染的预防或治疗剂的制备和用途。
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公开(公告)号：EP1809645A1
公开(公告)日：2007-07-25
申请号：EP05848094.8
申请日：2005-11-07
发明人： HANESSIAN, Stephen , SZYCHOWSKI, Janek , ADHIKARI, Susanta, Sekhar 17 Bagmari Lane , PACHAMUTHU, Kandasamy , MIGAWA, Michael, T. , GRIFFEY, Richard, H. , SWAYZE, Eric, E.
IPC分类号： C07H15/232 , A61P31/04 , A61K31/70
CPC分类号： C07H15/232
摘要： The present invention is directed to analogs of paromomycin having a variety of chemical functional groups attached at the 2”-O-positions as well as their preparation and use as prophylactic or therapeutics against microbial infection.
摘要翻译： 本发明涉及具有连接在2“-O-位上的各种化学官能团的巴龙霉素的类似物以及它们的制备和用作预防或治疗微生物感染的用途。
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公开(公告)号：EP2850092A1
公开(公告)日：2015-03-25
申请号：EP13714164.4
申请日：2013-03-20
发明人： SETH, Punit, P. , SWAYZE, Eric, E. , HANESSIAN, Stephen , SCHROEDER, Benjamin, R. , GIACOMETTI, Robert, D. , MERNER, Bradley, L.
摘要： The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. The tricyclic nucleosides each have a tricyclic ribosyl sugar moiety wherein a bridge between the 2' and 4' ribosyl ring carbon atoms further comprises a fused carbocyclic or heterocyclic ring. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.
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