发明公开
EP2897963A1 NOVEL GABAA AGONISTS AND METHODS OF USING TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
审中-公开
新型GABA促进剂和方法用于防治气道高反应和炎症哮喘
- 专利标题： NOVEL GABAA AGONISTS AND METHODS OF USING TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA
- 专利标题（中）： 新型GABA促进剂和方法用于防治气道高反应和炎症哮喘
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申请号： EP13838190.0申请日： 2013-09-20
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公开(公告)号： EP2897963A1公开(公告)日： 2015-07-29
- 发明人: STAFFORD, Douglas, C. , COOK, James, M. , ARNOLD, Alexander, E. , EMALA, Charles, W. , GALLOS, George , STEPHEN, Michael, Rajesh
- 申请人： UWM Research Foundation, Inc. , The Trustees of Columbia University in the City of New York
- 申请人地址： 1440 East North Avenue Milwaukee, WI 53202 US
- 专利权人： UWM Research Foundation, Inc.,The Trustees of Columbia University in the City of New York
- 当前专利权人： UWM Research Foundation, Inc.,The Trustees of Columbia University in the City of New York
- 当前专利权人地址： 1440 East North Avenue Milwaukee, WI 53202 US
- 代理机构： Dauncey, Mark Peter
- 优先权： US201261703902P 20120921
- 国际公布： WO2014047413 20140327
- 主分类号： C07D487/14
- IPC分类号： C07D487/14 ; A61K31/5517 ; A61P11/06 ; A61P29/00
摘要：
Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target alpha-4 and alpha-5 GABAA receptors and methods of using those compounds to treat bronchoconstriction and inflammation are provided herein.
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