发明公开
- 专利标题： TRIAZOLYL DERIVATIVES AS SYK INHIBITORS
- 专利标题（中）： 三氮唑衍生物作为SYK抑制剂
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申请号： EP13841430.5申请日： 2013-09-24
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公开(公告)号： EP2900665A1公开(公告)日： 2015-08-05
- 发明人: MACHACEK, Michelle R. , ROMEO, Eric T. , KATTAR, Solomon D. , CHRISTOPHER, Matthew , ALTMAN, Michael D. , NORTHRUP, Alan B. , ELLIS, John Michael , BOYLE, Brendan O' , DONOFRIO, Anthony , GRIMM, Jonathan , REUTERSHAN, Michael H. , CHILDERS, Kaleen Konrad , OTTE, Ryan D. , CASH, Brandon , DUCHARME, Yves , HAIDLE, Andrew M. , SPENCER, Kerrie , VITHARANA, Dilrukshi , WU, Lingyun , ZHANG, Li , ZHANG, Peng , BEAULIEU, Christian , GUAY, Daniel
- 申请人： Merck Sharp & Dohme Corp. , Merck Canada Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065 US
- 专利权人： Merck Sharp & Dohme Corp.,Merck Canada Inc.
- 当前专利权人： Merck Sharp & Dohme Corp.,Merck Canada Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065 US
- 代理机构： Hussain, Deeba
- 优先权： US201261707246P 20120928
- 国际公布： WO2014048065 20140403
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; C07D417/14 ; C07D239/50 ; A61K31/506 ; A61P11/06 ; A61P29/00 ; A61P35/00
摘要：
Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
公开/授权文献
- EP2900665B1 TRIAZOLYL DERIVATIVES AS SYK INHIBITORS 公开/授权日：2018-01-03
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