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公开(公告)号：EP2863916B1
公开(公告)日：2018-07-18
申请号：EP13807050.3
申请日：2013-06-17
发明人： HAIDLE, Andrew, M. , KNOWLES, Sandra Lee , KATTAR, Solomon, D. , DESCHENES, Denis , BURCH, Jason , ROBICHAUD, Joel , CHRISTOPHER, Matthew , ALTMAN, Michael, D. , JEWELL, James, P. , NORTHHRUP, Alan, B. , BLOUIN, Marc , ELLIS, John, Michael , ZHOU, Hua , FISCHER, Christian , SCHELL, Adam, J. , REUTERSHAN, Michael, H. , TAOKA, Brandon, M. , DONOFRIO, Anthony
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04 , A61K31/506 , A61P11/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D401/12 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04 , A61K2300/00
摘要： The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
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公开(公告)号：EP2863913B1
公开(公告)日：2018-09-12
申请号：EP13807108.9
申请日：2013-06-18
发明人： LIM, Jongwon , REUTERSHAN, Michael, H. , ELLIS, John Michael , CHILDERS, Kaleen Konrad , DONOFRIO, Anthony , ALTMAN, Michael, D. , HAIDLE, Andrew, M. , ZABIEREK, Anna , CHRISTOPHER, Matthew , GRIMM, Jonathan , BURCH, Jason , FRANCESCO, Maria Emilia Di , PETROCCHI, Alessia , BEAULIEU, Christian , TRUONG, Vouy Linh , NORTHRUP, Alan, B. , BLOUIN, Marc
IPC分类号： A61K31/50 , A61K31/501 , C07D401/14 , C07D403/14 , C07D403/12
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14
摘要： The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
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公开(公告)号：EP2900665A1
公开(公告)日：2015-08-05
申请号：EP13841430.5
申请日：2013-09-24
发明人： MACHACEK, Michelle R. , ROMEO, Eric T. , KATTAR, Solomon D. , CHRISTOPHER, Matthew , ALTMAN, Michael D. , NORTHRUP, Alan B. , ELLIS, John Michael , BOYLE, Brendan O' , DONOFRIO, Anthony , GRIMM, Jonathan , REUTERSHAN, Michael H. , CHILDERS, Kaleen Konrad , OTTE, Ryan D. , CASH, Brandon , DUCHARME, Yves , HAIDLE, Andrew M. , SPENCER, Kerrie , VITHARANA, Dilrukshi , WU, Lingyun , ZHANG, Li , ZHANG, Peng , BEAULIEU, Christian , GUAY, Daniel
IPC分类号： C07D417/12 , C07D417/14 , C07D239/50 , A61K31/506 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D401/14 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/4858 , C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 提供了式I的三唑衍生物，它们是有效的脾酪氨酸激酶抑制剂和药物组合物。 三唑衍生物可用于治疗和预防由所述酶介导的疾病，如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2513098A1
公开(公告)日：2012-10-24
申请号：EP10801736.9
申请日：2010-12-15
发明人： ALTMANN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , GUERIN, David Joseph , HAIDLE, Andrew M. , KATTAR, Solomon , KNOWLES, Sandra Lee , LI, Chaomin , LIM, Jongwon , MACHACEK, Michelle , NORTHRUP, Alan B. , O'BOYLE, Brendan M. , OTTE, Ryan D. , PETROCCHI, Alessia , REUTERSHAN, Michael H. , ROMEO, Eric , SIU, Tony , TAOKA, Brandon M. , TROTTER, B. Wesley , ZHOU, Hua , BURCH, Jason , COTE, Bernard , DUPONT-GAUDET, Kristina , FOURNIER, Jean-Francois , GAUTHIER, Jacques Yves , GUAY, Daniel , ROBICHAUD, Joel S. , GRIMM, Jonathan , MADDESS, Matthew L. , SCHELL, Adam J. , SPENCER, Kerrie B. , WOO, Hyun Chong , BHAT, Sathesh
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
摘要： The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
摘要翻译： 本发明提供了式（I）的新型嘧啶胺，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎。
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公开(公告)号：EP2706852B1
公开(公告)日：2018-08-22
申请号：EP12782391.2
申请日：2012-05-04
发明人： DESCHENES, Denis , ALTMAN, Michael D. , ELLIS, John Michael , FISCHER, Christian , HAIDLE, Andrew M. , KATTAR, Solomon D. , NORTHRUP, Alan B. , SCHELL, Adam J. , SMITH, Graham F. , TAOKA, Brandon M. , BIENSTOCK, Corey , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , PETERSON, Scott , SPENCER, Kerrie B. , JEWELL, James Patrick , ALI, Amjad , BENNETT, David Jonathan , DANG, Qun , WAI, John
IPC分类号： A01N43/40 , A61K31/44 , C07D213/04
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
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公开(公告)号：EP2988744A1
公开(公告)日：2016-03-02
申请号：EP14788026.4
申请日：2014-04-22
发明人： ANTHONY, Neville, J. , ANDRESEN, Brian, M. , NORTHRUP, Alan, B. , CHILDERS, Kaleen, K. , DONOFRIO, Anthony , MILLER, Thomas, A. , LIU, Yuan , MACHACEK, Michelle, R. , WOO, Hyun Chong , SPENCER, Kerrie, B. , ELLIS, John Michael , ALTMAN, Michael, D. , ROMEO, Eric, T. , GUAY, Daniel , GRIMM, Jonathan , LEBRUN, Marie-Eve , ROBICHAUD, Joel, S. , WANG, Liping , DUBOIS, Byron , DENG, Qiaolin
IPC分类号： A61K31/44 , A61K31/53 , A61K31/426
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D417/12
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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公开(公告)号：EP2863916A1
公开(公告)日：2015-04-29
申请号：EP13807050.3
申请日：2013-06-17
发明人： HAIDLE, Andrew, M. , KNOWLES, Sandra Lee , KATTAR, Solomon, D. , DESCHENES, Denis , BURCH, Jason , ROBICHAUD, Joel , CHRISTOPHER, Matthew , ALTMAN, Michael, D. , JEWELL, James, P. , NORTHHRUP, Alan, B. , BLOUIN, Marc , ELLIS, John, Michael , ZHOU, Hua , FISCHER, Christian , SCHELL, Adam, J. , REUTERSHAN, Michael, H. , TAOKA, Brandon, M. , DONOFRIO, Anthony
IPC分类号： A61K31/505 , A61P35/00
CPC分类号： C07D401/12 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04 , A61K2300/00
摘要： The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
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公开(公告)号：EP2863913A1
公开(公告)日：2015-04-29
申请号：EP13807108.9
申请日：2013-06-18
发明人： LIM, Jongwon , REUTERSHAN, Michael, H. , ELLIS, John Michael , CHILDERS, Kaleen Konrad , DONOFRIO, Anthony , ALTMAN, Michael, D. , HAIDLE, Andrew, M. , ZABIEREK, Anna , CHRISTOPHER, Matthew , GRIMM, Jonathan , BURCH, Jason , FRANCESCO, Maria Emilia Di , PETROCCHI, Alessia , BEAULIEU, Christian , TRUONG, Vouy Linh , NORTHRUP, Alan, B. , BLOUIN, Marc
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14
摘要： The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新咪唑类似物，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2900665B1
公开(公告)日：2018-01-03
申请号：EP13841430.5
申请日：2013-09-24
发明人： MACHACEK, Michelle R. , ROMEO, Eric T. , KATTAR, Solomon D. , CHRISTOPHER, Matthew , ALTMAN, Michael D. , NORTHRUP, Alan B. , ELLIS, John Michael , BOYLE, Brendan O' , DONOFRIO, Anthony , GRIMM, Jonathan , REUTERSHAN, Michael H. , CHILDERS, Kaleen Konrad , OTTE, Ryan D. , CASH, Brandon , DUCHARME, Yves , HAIDLE, Andrew M. , SPENCER, Kerrie , VITHARANA, Dilrukshi , WU, Lingyun , ZHANG, Li , ZHANG, Peng , BEAULIEU, Christian , GUAY, Daniel
IPC分类号： C07D417/12 , C07D417/14 , C07D239/50 , A61K31/506 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D401/14 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/4858 , C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
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公开(公告)号：EP2513098B1
公开(公告)日：2016-11-09
申请号：EP10801736.9
申请日：2010-12-15
发明人： ALTMANN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , GUERIN, David Joseph , HAIDLE, Andrew M. , KATTAR, Solomon , KNOWLES, Sandra Lee , LI, Chaomin , LIM, Jongwon , MACHACEK, Michelle , NORTHRUP, Alan B. , O'BOYLE, Brendan M. , OTTE, Ryan D. , PETROCCHI, Alessia , REUTERSHAN, Michael H. , ROMEO, Eric , SIU, Tony , TAOKA, Brandon M. , TROTTER, B. Wesley , ZHOU, Hua , BURCH, Jason , COTE, Bernard , DUPONT-GAUDET, Kristina , FOURNIER, Jean-Francois , GAUTHIER, Jacques Yves , GUAY, Daniel , ROBICHAUD, Joel S. , GRIMM, Jonathan , MADDESS, Matthew L. , SCHELL, Adam J. , SPENCER, Kerrie B. , WOO, Hyun Chong , BHAT, Sathesh
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
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