- 专利标题: SOLVENTLESS MIXING PROCESS FOR COATING PHARMACEUTICAL INGREDIENTS
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申请号: EP13780276.5申请日: 2013-10-09
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公开(公告)号: EP2906205B1公开(公告)日: 2018-06-13
- 发明人: DAVE, Rajesh, N. , TO, Daniel , CAPECE, Maxx
- 申请人: New Jersey Institute of Technology
- 申请人地址: University Heights 323 Dr. Martin Luther King Jr. Blvd. Newark, NJ 07102-1982 US
- 专利权人: New Jersey Institute of Technology
- 当前专利权人: New Jersey Institute of Technology
- 当前专利权人地址: University Heights 323 Dr. Martin Luther King Jr. Blvd. Newark, NJ 07102-1982 US
- 代理机构: Dunleavy, Kevin James
- 优先权: US201213651977 20121015
- 国际公布: WO2014062444 20140424
- 主分类号: A61K9/60
- IPC分类号: A61K9/60 ; A61K9/62
摘要:
The present invention is a solventless method of producing polymer coated active pharmaceutical ingredient that is taste-masked and may be released in relatively short time. It employs high energy vibrations or acoustic mixing of API particles, water soluble coating material particles and hydrophobic polymer particles, with or without use of other pharmaceutically relevant powders as media. Additionally the method is capable of producing individually coated drug particles without agglomeration or the long drying times associated with solvent based coating methods.
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