发明公开
EP2916824A1 PHARMACEUTICAL CORE-SHELL COMPOSITE POWDER AND PROCESSES FOR MAKING THE SAME
审中-公开
药物的皮芯型复合粉体的方法及其制造
- 专利标题: PHARMACEUTICAL CORE-SHELL COMPOSITE POWDER AND PROCESSES FOR MAKING THE SAME
- 专利标题(中): 药物的皮芯型复合粉体的方法及其制造
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申请号: EP13852722.1申请日: 2013-11-08
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公开(公告)号: EP2916824A1公开(公告)日: 2015-09-16
- 发明人: AZAD, Mohammed A. , BILGILI, Ecevit A. , TO, Daniel , KNIEKE, Catharina , DAVE, Rajesh
- 申请人: New Jersey Institute of Technology
- 申请人地址: University Heights 323 Dr. Martin Luther King Jr. Blvd. Newark, NJ 07102-1982 US
- 专利权人: New Jersey Institute of Technology
- 当前专利权人: New Jersey Institute of Technology
- 当前专利权人地址: University Heights 323 Dr. Martin Luther King Jr. Blvd. Newark, NJ 07102-1982 US
- 代理机构: Dunleavy, Kevin James
- 优先权: US201261725301P 20121112
- 国际公布: WO2014074808 20140515
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K9/16 ; A61K47/30
摘要:
A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.
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