发明公开
EP2937341A1 4-(BENZYL)-PIPERAZINE-1-CARBOXYLIC ACID PHENYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE (FAAH) FOR THE TREATMENT OF ANXIETY, PAIN AND OTHER CONDITIONS
有权
4-(苄基)哌嗪-1-甲酸苯基酰胺衍生物和相关化合物作为脂肪酸酰胺水解酶(FAAH)的FOR焦虑状态,疼痛和其他疾病的治疗调节剂
- 专利标题: 4-(BENZYL)-PIPERAZINE-1-CARBOXYLIC ACID PHENYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE (FAAH) FOR THE TREATMENT OF ANXIETY, PAIN AND OTHER CONDITIONS
- 专利标题(中): 4-(苄基)哌嗪-1-甲酸苯基酰胺衍生物和相关化合物作为脂肪酸酰胺水解酶(FAAH)的FOR焦虑状态,疼痛和其他疾病的治疗调节剂
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申请号: EP15160349.5申请日: 2005-12-29
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公开(公告)号: EP2937341A1公开(公告)日: 2015-10-28
- 发明人: Apodaca, Richard , Breitenbucher, J., Guy , Pattabiraman, Kanaka , Seierstad, Mark , Xiao, Wei
- 申请人: Janssen Pharmaceutica N.V.
- 申请人地址: Turnhoutseweg 30 2340 Beerse BE
- 专利权人: Janssen Pharmaceutica N.V.
- 当前专利权人: Janssen Pharmaceutica N.V.
- 当前专利权人地址: Turnhoutseweg 30 2340 Beerse BE
- 代理机构: Carpmaels & Ransford LLP
- 优先权: US640869P 20041230
- 主分类号: C07D317/58
- IPC分类号: C07D317/58 ; C07D319/18 ; C07D295/20 ; C07D215/12 ; C07D401/12 ; C07D405/12 ; C07D239/42 ; C07D241/42 ; C07D417/12 ; C07C275/28 ; A61K31/495 ; A61K31/496 ; A61P25/22 ; A61P25/04 ; A61P25/28
摘要:
Compounds of formula (I): wherein, Z is -N- or >CH; R 1 is -H or -C 1-4 alkyl; Ar 1 is 2-thiazoly, 2-pyridy, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-primidinyl, 5-pyrimidinyl, or phenyl, each unsubstituted or substituted at a carbon ring member with one or two R a moieties; where each R a moiety is independently selected from the group consisting of -C 1-4 alkyl, -C 2-4 alkenyl, -OH, -OC 1-4 alkyl, halo -CF 3 , -OCF 3 , -SCF 3 , -SH, -S(O) 0-2 C 1-4 alkyl, -OSO 2 C 1-4 alkyl, -CO 2 C 1-4 alkyl, -CO 2 H, -COC 1-4 alkyl, -N(R b )R c , -SO 2 NR b R c , -NR b SO 2 R, -C(=O)NR b R c , -NO 2 , and -CN, wherein R b and R c are each independently -H or -C 1-4 alkyl; and Ar 2 is defined in the claims are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).
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