发明公开
EP2970266A1 1 -PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF
有权
1-戊烯-3-(烷基氨基)丙酰胺-2-衍生物ALM CARM1-INHIBITOREN UND VERWENDUNG DAVON
- 专利标题: 1 -PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF
- 专利标题(中): 1-戊烯-3-(烷基氨基)丙酰胺-2-衍生物ALM CARM1-INHIBITOREN UND VERWENDUNG DAVON
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申请号: EP14717046.8申请日: 2014-03-14
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公开(公告)号: EP2970266A1公开(公告)日: 2016-01-20
- 发明人: CHESWORTH, Richard , MORADEL, Oscar Miguel , SHAPIRO, Gideon , DUNCAN, Kenneth W. , MITCHELL, Lorna Helen , JIN, Lei , BABINE, Robert E.
- 申请人: Epizyme, Inc.
- 申请人地址: 400 Technology Square, 4th Floor Cambridge, MA 02139 US
- 专利权人: Epizyme, Inc.
- 当前专利权人: Epizyme, Inc.
- 当前专利权人地址: 400 Technology Square, 4th Floor Cambridge, MA 02139 US
- 代理机构: Harris, Jennifer Lucy
- 优先权: US201361798109P 20130315
- 国际公布: WO2014144455 20140918
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; C07D487/04 ; A61P35/00 ; A61K31/519 ; A61K31/437
摘要:
Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R1, R2a, R2b, R2c, R2d, are as defined herein, and Ring HET is an optionally substituted 6,5-bicyclic heteroaryl ring system comprising 2 to 5 nitrogen atoms, inclusive, wherein the point of attachment is provided on the 6-membered ring of the 6,5-bicyclic heteroaryl ring system, and wherein the 6-membered ring is further substituted with a group of formula -L1-R3, wherein L1 and R3 are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.
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