-
公开(公告)号：EP4360712A2
公开(公告)日：2024-05-01
申请号：EP23217912.7
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen , KUNTZ, Kevin Wayne
IPC分类号： A61P35/00
CPC分类号： C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D405/14 , A61K31/5377 , A61P25/00 , A61P35/00 , A61P35/02 , A61P43/00
摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
-
公开(公告)号：EP2892536B1
公开(公告)日：2019-12-18
申请号：EP13835189.5
申请日：2013-09-06
申请人： Epizyme, Inc.
发明人： OLHAVA, Edward, J. , CHESWORTH, Richard , KUNTZ, Kevin, W. , RICHON, Victoria, M. , POLLOCK, Roy, M. , DAIGLE, Scott, Richard
IPC分类号： A61K31/52 , A61K31/4184 , A61P35/02 , A61K31/7076
-
公开(公告)号：EP3486234A1
公开(公告)日：2019-05-22
申请号：EP18200713.8
申请日：2012-04-13
申请人： Epizyme Inc
发明人： CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen , KUNTZ, Kevin Wayne
IPC分类号： C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , A61K31/4412 , A61K31/444 , A61P35/00
摘要： The present invention relates to aryl- or heteroaryl-substituted benzene compounds (I) for use in treating a cell proliferative disorder.
-
公开(公告)号：EP3470396A1
公开(公告)日：2019-04-17
申请号：EP18189032.8
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： KUNTZ, Kevin Wayne , CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , KNUTSON, Sarah , WIGLE, Timothy James Nelson
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/10 , C07D491/113 , A61K31/4427 , A61P35/00
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and such compounds for use in treating cancer. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
-
公开(公告)号：EP3165520B1
公开(公告)日：2018-08-15
申请号：EP16173275.5
申请日：2012-04-13
申请人： Epizyme Inc
发明人： KUNTZ, Kevin Wayne , CHESWORTH, Richard , DUNCAN, Kenneth William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , KNUTSON, Sarah , WIGLE, Timothy James Nelson
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/10 , C07D491/113 , A61K31/4427 , A61P35/00
CPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/048 , C07D491/08 , C07D491/10 , C07D491/113
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and such compounds for use in treating cancer. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
-
公开(公告)号：EP3193608A1
公开(公告)日：2017-07-26
申请号：EP15842456.4
申请日：2015-09-17
申请人： Epizyme, Inc.
IPC分类号： A01N47/10
CPC分类号： C07D487/10 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/14 , C07D491/107 , C07D491/113 , C07D493/04 , C07D498/04 , C07D498/08 , C07D513/04
摘要： Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2a, R2b, R3 and Ring B are as defined herein, and Ring A is a group of Formula (A-i), (A-ii), or (A-iii): wherein R, R, R, R, and R are as defined herein. Compounds of the present invention are useful for inhibiting CARMl activity. Methods of using the compounds for treating CARMl -mediated disorders are also described.
摘要翻译： 本文提供了式（I）化合物及其药学上可接受的盐及其药物组合物，其中R 1，R 2a，R 2b，R 3和环B如本文所定义，且环A为式（Ai）， A-ii）或（A-iii）：其中R，R，R，R和R如本文所定义。 本发明的化合物可用于抑制CARM1活性。 还描述了使用该化合物治疗CARM1介导的病症的方法。
-
公开(公告)号：EP3193605A1
公开(公告)日：2017-07-26
申请号：EP15840497.0
申请日：2015-09-09
申请人： Epizyme, Inc.
发明人： MITCHELL, Lorna Helen , BELL, Andrew Simon , CHESWORTH, Richard , FOLEY, Megan Alene Cloonan , KUNTZ, Kevin Wayne , MILLS, James Edward John , MUNCHHOF, Michael John
IPC分类号： A01N43/80
CPC分类号： C07D451/04 , A61P35/00 , C07D413/12 , C07D413/14 , C07D487/08 , C07D519/00
摘要： The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
摘要翻译： 本公开提供了具有式（I）的取代的哌啶化合物及其药学上可接受的盐和溶剂合物，其中R 1，B，X和Z如说明书中所定义。 本公开还涉及式I化合物用于治疗响应于SMYD蛋白质例如SMYD3或SMYD2的阻断的病症的用途。 本公开的化合物对于治疗癌症尤其有用。
-
公开(公告)号：EP3177288A1
公开(公告)日：2017-06-14
申请号：EP15830530.0
申请日：2015-08-04
发明人： DUNCAN, Kenneth W. , CHESWORTH, Richard , BORIACK-SJODIN, Paula Ann , MUNCHHOF, Michael John , JIN, Lei , PENEBRE, Elayne , BARBASH, Olena I.
IPC分类号： A61K31/44 , A61K31/535 , A61K31/00
CPC分类号： A61K31/506 , A61K31/4725 , A61K31/513 , A61K45/06 , A61P35/00 , A61K31/4545 , A61K2300/00
摘要： Described herein are methods of treating cancer using one or more PRMT5 inhibitors, for example using one or more compounds of Formulae (1-5) or (A-F), pharmaceutically acceptable salts thereof, and/or pharmaceutical compositions thereof. Described herein are methods of treating cancer using one or more PRMT5 inhibitors, for example using one or more compounds of Formulae (1-5) or (A-F), pharmaceutically acceptable salts thereof, and/or pharmaceutical compositions thereof.
摘要翻译： 本文描述了使用一种或多种PRMT5抑制剂，例如使用一种或多种式（1-5）或（A-F）的化合物，其药学上可接受的盐和/或其药物组合物治疗癌症的方法。 本文描述了使用一种或多种PRMT5抑制剂，例如使用一种或多种式（1-5）或（A-F）的化合物，其药学上可接受的盐和/或其药物组合物治疗癌症的方法。
-
公开(公告)号：EP3160466A2
公开(公告)日：2017-05-03
申请号：EP15812795.1
申请日：2015-06-25
申请人： Epizyme, Inc.
IPC分类号： A61K31/4353
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/506 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (ϰ) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V4, V5, Rx, x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
摘要翻译： 本文描述了式（A）的化合物，其药学上可接受的盐及其药物组合物：其中Y 1具有式（κ）或式（y）：环Y为5-至6-元杂芳基环; 和V4，V5，Rx，x，y和n如本文所定义。 本发明的化合物可用于抑制PRMT5活性。 还描述了使用该化合物治疗PRMT5介导的病症的方法。
-
公开(公告)号：EP2697199B1
公开(公告)日：2016-06-08
申请号：EP12719529.5
申请日：2012-04-13
申请人： Epizyme, Inc.
发明人： KUNTZ, Kevin, Wayne , CHESWORTH, Richard , DUNCAN, Kenneth, William , KEILHACK, Heike , WARHOLIC, Natalie , KLAUS, Christine , SEKI, Masashi , SHIROTORI, Syuji , KAWANO, Satoshi , WIGLE, Timothy James Nelson , KNUTSON, Sarah Kathleen
IPC分类号： C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , A61K31/4412 , A61K31/444 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
-
-
-
-
-
-
-
-
-
搜索结果
67 条记录 (耗时 0.069 秒)
