发明授权
EP2986605B1 ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF
有权
作为细胞周期蛋白依赖性激酶抑制剂的类固醇类似物及其制备方法
- 专利标题： ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF
- 专利标题（中）： 作为细胞周期蛋白依赖性激酶抑制剂的类固醇类似物及其制备方法
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申请号： EP14734915.3申请日： 2014-04-16
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公开(公告)号： EP2986605B1公开(公告)日： 2017-11-15
- 发明人: VISHWAKARMA, Ram Asrey , BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MONDHE, Dilip Manikrao , JAIN, Shreyans Kumar , MEENA, Samdarshi , GURU, Santosh Kumar , PATHANIA, Anup Singh , KUMAR, Suresh , BEHL, Akanksha , MINTOO, Mubashir Javed , BHARATE, Sonali Sandip , JOSHI, Prashant
- 申请人： Council of Scientific and Industrial Research
- 申请人地址： Anusandhan Bhawan Rafi Marg New Delhi 110001 IN
- 专利权人： Council of Scientific and Industrial Research
- 当前专利权人： Council of Scientific and Industrial Research
- 当前专利权人地址： Anusandhan Bhawan Rafi Marg New Delhi 110001 IN
- 代理机构： Awapatent AB
- 优先权： IN1142DE2013 20130417
- 国际公布： WO2014170914 20141023
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; C07D405/04 ; A61P35/00 ; A61K31/453
摘要：
The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.
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