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1.发明公开ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF 有权ROHITUKIN-ANALOGA ALSCYCLINABHÄNGIGEKINASEINHIBITOREN UND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP2986605A1
公开(公告)日：2016-02-24
申请号：EP14734915.3
申请日：2014-04-16
发明人： VISHWAKARMA, Ram Asrey , BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MONDHE, Dilip Manikrao , JAIN, Shreyans Kumar , MEENA, Samdarshi , GURU, Santosh Kumar , PATHANIA, Anup Singh , KUMAR, Suresh , BEHL, Akanksha , MINTOO, Mubashir Javed , BHARATE, Sonali Sandip , JOSHI, Prashant
IPC分类号： C07D405/14 , C07D405/04 , A61P35/00 , A61K31/453
CPC分类号： C07D405/04 , C07D405/14
摘要： The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.
摘要翻译： 本发明涉及式A的类胡萝卜素（5,7-二羟基-8-（3-羟基-1-甲基 - 哌啶-4-基）-4H-色烯-4-酮）类似物及其药学上可接受的盐。 此外，本发明涉及包含至少一种这样的化合物的药学上可接受的组合物，以及使用该化合物治疗或预防各种增殖性疾病如黑素瘤，白血病，乳腺癌和前列腺癌等的方法。[此处插入式A]其中 ，n = 0或1，当n = 1时，虚线表示双键。
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公开(公告)号：EP3380476B1
公开(公告)日：2020-09-30
申请号：EP16834199.8
申请日：2016-11-21
发明人： BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MOHAMMED, Shabber , GURU, Santosh Kumar , BHARATE, Sonali Sandip , KUMAR, Vikas , MAHAJAN, Girish , MINTOO, Mubashir Javed , MONDHE, Dilip Manikrao , VISHWAKARMA, Ram
IPC分类号： C07D491/147 , C07D495/04 , A61K31/519 , A61K31/5377 , A61P35/00
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3.发明授权ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF 有权作为细胞周期蛋白依赖性激酶抑制剂的类固醇类似物及其制备方法
公开(公告)号：EP2986605B1
公开(公告)日：2017-11-15
申请号：EP14734915.3
申请日：2014-04-16
发明人： VISHWAKARMA, Ram Asrey , BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MONDHE, Dilip Manikrao , JAIN, Shreyans Kumar , MEENA, Samdarshi , GURU, Santosh Kumar , PATHANIA, Anup Singh , KUMAR, Suresh , BEHL, Akanksha , MINTOO, Mubashir Javed , BHARATE, Sonali Sandip , JOSHI, Prashant
IPC分类号： C07D405/14 , C07D405/04 , A61P35/00 , A61K31/453
CPC分类号： C07D405/04 , C07D405/14
摘要： The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.
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4.发明公开
公开(公告)号：EP3380476A1
公开(公告)日：2018-10-03
申请号：EP16834199.8
申请日：2016-11-21
发明人： BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MOHAMMED, Shabber , GURU, Santosh Kumar , BHARATE, Sonali Sandip , KUMAR, Vikas , MAHAJAN, Girish , MINTOO, Mubashir Javed , MONDHE, Dilip Manikrao , VISHWAKARMA, Ram
IPC分类号： C07D491/147 , C07D495/04 , A61K31/519 , A61K31/5377 , A61P35/00
摘要： The present invention relates to fused pyrimidines of formulae I and II wherein, R1, R2 are as herein described. The present invention particularly relates to isoform selective PI3Kα inhibition and their medicinal use as anticancer agents.
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