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1.发明公开ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF 有权ROHITUKIN-ANALOGA ALSCYCLINABHÄNGIGEKINASEINHIBITOREN UND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP2986605A1
公开(公告)日：2016-02-24
申请号：EP14734915.3
申请日：2014-04-16
发明人： VISHWAKARMA, Ram Asrey , BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MONDHE, Dilip Manikrao , JAIN, Shreyans Kumar , MEENA, Samdarshi , GURU, Santosh Kumar , PATHANIA, Anup Singh , KUMAR, Suresh , BEHL, Akanksha , MINTOO, Mubashir Javed , BHARATE, Sonali Sandip , JOSHI, Prashant
IPC分类号： C07D405/14 , C07D405/04 , A61P35/00 , A61K31/453
CPC分类号： C07D405/04 , C07D405/14
摘要： The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.
摘要翻译： 本发明涉及式A的类胡萝卜素（5,7-二羟基-8-（3-羟基-1-甲基 - 哌啶-4-基）-4H-色烯-4-酮）类似物及其药学上可接受的盐。 此外，本发明涉及包含至少一种这样的化合物的药学上可接受的组合物，以及使用该化合物治疗或预防各种增殖性疾病如黑素瘤，白血病，乳腺癌和前列腺癌等的方法。[此处插入式A]其中 ，n = 0或1，当n = 1时，虚线表示双键。
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2.发明公开
公开(公告)号：EP3380476A1
公开(公告)日：2018-10-03
申请号：EP16834199.8
申请日：2016-11-21
发明人： BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MOHAMMED, Shabber , GURU, Santosh Kumar , BHARATE, Sonali Sandip , KUMAR, Vikas , MAHAJAN, Girish , MINTOO, Mubashir Javed , MONDHE, Dilip Manikrao , VISHWAKARMA, Ram
IPC分类号： C07D491/147 , C07D495/04 , A61K31/519 , A61K31/5377 , A61P35/00
摘要： The present invention relates to fused pyrimidines of formulae I and II wherein, R1, R2 are as herein described. The present invention particularly relates to isoform selective PI3Kα inhibition and their medicinal use as anticancer agents.
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公开(公告)号：EP3380476B1
公开(公告)日：2020-09-30
申请号：EP16834199.8
申请日：2016-11-21
发明人： BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MOHAMMED, Shabber , GURU, Santosh Kumar , BHARATE, Sonali Sandip , KUMAR, Vikas , MAHAJAN, Girish , MINTOO, Mubashir Javed , MONDHE, Dilip Manikrao , VISHWAKARMA, Ram
IPC分类号： C07D491/147 , C07D495/04 , A61K31/519 , A61K31/5377 , A61P35/00
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公开(公告)号：EP3697389A1
公开(公告)日：2020-08-26
申请号：EP18796784.9
申请日：2018-10-04
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公开(公告)号：EP3781133A1
公开(公告)日：2021-02-24
申请号：EP19723887.6
申请日：2019-04-18
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公开(公告)号：EP3207026B1
公开(公告)日：2018-12-12
申请号：EP15805323.1
申请日：2015-10-14
发明人： VISHWAKARMA, Ram , BHARATE, Sandip Bibishan , KUMAR, Ajay , SINGH, Baljinder , KUMAR, Ashok , BHUSHAN, Shashi , HAMID, Abid , JOSHI, Prashant , GURU, Santosh Kumar , KUMAR, Suresh , HUSSAIN, Aashiq , QAZI, Asif Khurshid , BHARATE, Sonali Sandip , SHARMA, Parduman , SAXENA, Ajit Kumar , MONDHE, Dilip Manikrao , MAHAJAN, Girish , WANI, Zahoor
IPC分类号： C07C233/41
CPC分类号： C07C233/41 , A61K31/165 , C07C231/12 , C07C2603/34
摘要： The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.
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7.发明授权ROHITUKINE ANALOGS AS CYCLIN-DEPENDENT KINASE INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF 有权作为细胞周期蛋白依赖性激酶抑制剂的类固醇类似物及其制备方法
公开(公告)号：EP2986605B1
公开(公告)日：2017-11-15
申请号：EP14734915.3
申请日：2014-04-16
发明人： VISHWAKARMA, Ram Asrey , BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MONDHE, Dilip Manikrao , JAIN, Shreyans Kumar , MEENA, Samdarshi , GURU, Santosh Kumar , PATHANIA, Anup Singh , KUMAR, Suresh , BEHL, Akanksha , MINTOO, Mubashir Javed , BHARATE, Sonali Sandip , JOSHI, Prashant
IPC分类号： C07D405/14 , C07D405/04 , A61P35/00 , A61K31/453
CPC分类号： C07D405/04 , C07D405/14
摘要： The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc. [insert Formula A here] wherein, n=0 or 1, when n=1, the dotted line indicates the double bond.
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公开(公告)号：EP3207026A1
公开(公告)日：2017-08-23
申请号：EP15805323.1
申请日：2015-10-14
发明人： VISHWAKARMA, Ram , BHARATE, Sandip Bibishan , KUMAR, Ajay , SINGH, Baljinder , KUMAR, Ashok , BHUSHAN, Shashi , HAMID, Abid , JOSHI, Prashant , GURU, Santosh Kumar , KUMAR, Suresh , HUSSAIN, Aashiq , QAZI, Asif Khurshid , BHARATE, Sonali Sandip , SHARMA, Parduman , SAXENA, Ajit Kumar , MONDHE, Dilip Manikrao , MAHAJAN, Girish , WANI, Zahoor
IPC分类号： C07C233/41
CPC分类号： C07C233/41 , A61K31/165 , C07C231/12 , C07C2603/34
摘要： The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.
摘要翻译： 本发明涉及式I化合物，其中R如本文所述。 本发明特别涉及10-取代的类秋水仙碱的合成和抗增殖活性。 本发明的化合物可以用于预防或治疗癌症疾病。
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