发明公开
EP2997032A1 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
有权
6-VERBRÜCKTE异噻唑啉衍生物ZUR BEHANDLUNG UND PROPHYLAXE VON HEPATITIS-B-VIRUS-INFEKTIONEN
- 专利标题： 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
- 专利标题（中）： 6-VERBRÜCKTE异噻唑啉衍生物ZUR BEHANDLUNG UND PROPHYLAXE VON HEPATITIS-B-VIRUS-INFEKTIONEN
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申请号： EP14724735.7申请日： 2014-05-16
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公开(公告)号： EP2997032A1公开(公告)日： 2016-03-23
- 发明人: GUO, Lei , HU, Taishan , HU, Yimin , KOCER, Buelent , KOU, Buyu , LI, Gangqin , LIN, Xianfeng , LIU, Haixia , SHEN, Hong , SHI, Houguang , WU, Guolong , ZHANG, Zhisen , ZHOU, Mingwei , ZHU, Wei
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Halbig, Dirk
- 优先权： PCT/CN2013/075815 20130517; PCT/CN2014/075392 20140415
- 国际公布： WO2014184328 20141120
- 主分类号： C07D491/08
- IPC分类号： C07D491/08 ; C07D453/06 ; C07D471/08 ; C07D487/08 ; C07D491/18 ; A61K31/506 ; A61P31/12
摘要：
The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
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