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1.发明授权NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权新的4-甲基 - 二氢嘧啶可用于治疗和预防乙型肝炎病毒感染的
公开(公告)号：EP2831060B1
公开(公告)日：2016-05-04
申请号：EP13712263.6
申请日：2013-03-26
发明人： GUO, Lei , LIN, Xianfeng , LIU, Haixia , QIU, Zongxing , SHEN, Hong , TANG, Guozhi , WU, Guolong , ZHANG, Weixing , ZHU, Wei
IPC分类号： C07D401/14 , C07D413/14 , A61K31/506 , C07D403/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61P31/12
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
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2.发明公开6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权6-VERBRÜCKTE异噻唑啉衍生物ZUR BEHANDLUNG UND PROPHYLAXE VON HEPATITIS-B-VIRUS-INFEKTIONEN
公开(公告)号：EP2997032A1
公开(公告)日：2016-03-23
申请号：EP14724735.7
申请日：2014-05-16
发明人： GUO, Lei , HU, Taishan , HU, Yimin , KOCER, Buelent , KOU, Buyu , LI, Gangqin , LIN, Xianfeng , LIU, Haixia , SHEN, Hong , SHI, Houguang , WU, Guolong , ZHANG, Zhisen , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D491/08 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/18 , A61K31/506 , A61P31/12
CPC分类号： C07D498/18 , A61K31/506 , C07D417/14 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D498/08 , C07D498/20 , C07D513/08
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其药学上可接受的盐或互变异构体异构体或其对映异构体或非对映异构体。 本发明还包含包含化合物的组合物和使用该化合物的方法。
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3.发明公开6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权6-氨基HETEROARYLDIHYDROPYRIMIDINE用于治疗和预防乙型肝炎病毒INFECTION-
公开(公告)号：EP2892893A1
公开(公告)日：2015-07-15
申请号：EP13763201.4
申请日：2013-09-06
发明人： GUO, Lei , HU, Taishan , HU, Yimin , KOCER, Buelent , LIN, Xianfeng , LIU, Haixia , MAYWEG, Alexander V. , QIU, Zongxing , SHEN, Hong , TANG, Guozhi , WANG, Lisha , WU, Guolong , YAN, Shixiang , ZHANG, Weixing , ZHOU, Mingwei , ZHU, Wei
IPC分类号： C07D401/14 , C07D413/14 , C07D403/06 , C07D409/14 , C07D417/14 , A61K31/506 , A61K31/5355 , A61P31/20
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , A61K2300/00
摘要： The invention provides novel compounds having the general formula:, wherein R
1 , R
2 , R
3 , R
4 and A are as described herein, compositions including the compounds and methods of using the compounds.-
4.发明公开NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权新的4-甲基 - 二氢嘧啶可用于治疗和预防乙型肝炎病毒感染的
公开(公告)号：EP2831060A1
公开(公告)日：2015-02-04
申请号：EP13712263.6
申请日：2013-03-26
发明人： GUO, Lei , LIN, Xianfeng , LIU, Haixia , QIU, Zongxing , SHEN, Hong , TANG, Guozhi , WU, Guolong , ZHANG, Weixing , ZHU, Wei
IPC分类号： C07D401/14 , C07D413/14 , A61K31/506 , C07D403/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61P31/12
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention provides novel compounds having the general formula (I): wherein R
1 , R
2 , R
3 , R
4 , R
5 , M and X are as described herein, compositions including the compounds and methods of using the compounds.
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