公开(公告)号：EP4482837A1

公开(公告)日：2025-01-01

申请号：EP23713248.5

申请日：2023-02-27

Applicant: Recludix Pharma, Inc.

Inventor： BIFULCO, Neil ,  BREGMAN, Howard ,  CIANCHETTA, Giovanni ,  HODOUS, Brian ,  REZNIK, Samuel, K. ,  TANG, Yong ,  TASKER, Andrew ,  VASWANI, Rishi, G. ,  SICKMIER, Ernest, Allen ,  YEOMAN, John ,  TIAN, Xia

IPC: C07D487/04 ,  C07D513/04 ,  C07D471/04 ,  C07D453/06 ,  C07F9/6561 ,  A61K31/551 ,  A61K31/554 ,  A61P35/00 ,  A61P29/00 ,  A61P43/00

公开(公告)号：EP4448512A1

公开(公告)日：2024-10-23

申请号：EP22908423.1

申请日：2022-12-15

Applicant: Aligos Therapeutics, Inc.

Inventor： WU, Tongfei ,  RABOISSON, Pierre Jean-Marie Bernard ,  GONZALVEZ, Francois

IPC: C07D401/14 ,  A61K31/501 ,  A61K31/513 ,  A61P31/20 ,  A61P35/00 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D453/06 ,  C07D487/10 ,  C07D498/04

公开(公告)号：EP2886540A4

公开(公告)日：2015-06-24

申请号：EP13829720

申请日：2013-08-14

Applicant: XUANZHU PHARMA CO LTD

Inventor： WU FRANK ,  WANG AICHEN

IPC: C07D403/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  A61P13/02 ,  A61P15/10 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D453/06 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  C07D498/08

CPC classification number: C07D491/08 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/00 ,  C07D239/47 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D453/06 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  C07D498/08

公开(公告)号：EP1781290B1

公开(公告)日：2010-12-08

申请号：EP05794113.0

申请日：2005-08-10

Applicant: Cambridge Enterprise Limited

Inventor： GRAINGER, David John, Dept. Med. Cambridge Univ. ,  FOX, David John Dept. of Chemistry University of Warwick

IPC: A61K31/439 ,  A61K31/55 ,  C07D453/06 ,  C07D487/08 ,  A61P31/12 ,  A61P19/10 ,  A61P11/06 ,  A61P19/02 ,  A61P17/02 ,  A61P37/00 ,  A61P25/28

CPC classification number: A61K31/55 ,  A61K31/439 ,  C07D451/14

Abstract: The invention provides compounds, compositions, and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, for the preparation of a medicament intended to treat an inflammatory disorder wherein y is any integer from 1 to 8; z is any integer from 1 to 8; with the proviso that y and z cannot both equal 1; X is -C -(Y)k-(R1)n or SO2-(Y)k (R1)n; k is 0 or 1; Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or Y is a cycloalkenyl or polycycloalkenyl group.

公开(公告)号：EP1819342A4

公开(公告)日：2008-12-17

申请号：EP05852416

申请日：2005-11-29

Applicant: MERCK & CO INC

Inventor： DEVITA ROBERT J ,  JIANG JINLONG ,  MILLS SANDER G

IPC: A61K31/535 ,  A61P25/00 ,  C07D207/04 ,  C07D211/70 ,  C07D215/20 ,  C07D215/38 ,  C07D215/48 ,  C07D215/60 ,  C07D453/06

CPC classification number: C07D215/20 ,  C07D215/38 ,  C07D215/48 ,  C07D215/60 ,  C07D453/06

公开(公告)号：EP1994015A1

公开(公告)日：2008-11-26

申请号：EP07705669.5

申请日：2007-02-28

Applicant: Pfizer Products Inc.

Inventor： CHANG, George ,  GARIGIPATI, Ravi, Shanker ,  LEFKER, Bruce, Allen ,  PERRY, David, Austen

IPC: C07D257/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  A61K31/40 ,  A61P9/00 ,  C07D417/12 ,  C07D453/06 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04 ,  C07D413/12

CPC classification number: C07D257/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D453/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D513/04

Abstract: Dibenzyl amine compounds and derivatives, of Formula (I), pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

Abstract translation: 式（I）的二苄基胺化合物和衍生物，含有这些化合物的药物组合物和这些化合物用于提高某些血浆脂质水平（包括高密度脂蛋白 - 胆固醇）并降低某些其他血浆脂质水平如LDL-胆固醇的用途 和甘油三酯，并因此治疗某些哺乳动物（包括人类）中由低HDL胆固醇和/或高水平的LDL-胆固醇和甘油三酯（例如动脉粥样硬化和心血管疾病）加剧的疾病。

公开(公告)号：EP1879887A2

公开(公告)日：2008-01-23

申请号：EP06743700.4

申请日：2006-04-14

Applicant: Cerep

Inventor： BOTEZ, Iuliana ,  DAVID-BASEI, Christelle ,  GOURLAOUËN, Nelly ,  NICOLAÏ, Eric ,  BALAVOINE, Fabrice ,  VALETTE, Gérard ,  SERRADEIL-LE GAL, Claudine

IPC: C07D417/12 ,  C07D401/12 ,  C07D413/12 ,  C07D453/06 ,  C07D471/08 ,  C07D211/42 ,  C07D211/46 ,  A61K31/452 ,  A61P3/00

CPC classification number: C07D295/088 ,  C07D211/42 ,  C07D211/46 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D453/06 ,  C07D471/08

Abstract: The invention relates to novel compounds, to the preparation and use thereof, in particular therapeutic. Said invention particularly relates to derived compounds comprising at least two aromatic cycles, to the preparation and use thereof, mainly for human and animal health care. Said compounds exhibit an affinity to biological receptors Y and NPY of a neuropeptide Y which are present in the central and peripheral nervous systems. The inventive compounds are preferably embodied in the form NPY antagonists, and more particularly in the form of NPY Y1 subtype antagonists and, whereby are usable in therapeutic or prophylactic treatment all NPY involving disorders. Pharmaceutical compositions comprising said compounds, the preparation and the use thereof and treating methods using said compounds are also disclosed.

公开(公告)号：EP0937069B1

公开(公告)日：2006-05-03

申请号：EP97912827.9

申请日：1997-10-28

Applicant: SCHERING CORPORATION

Inventor： BLYTHIN, David, J. ,  CHEN, Xiao ,  FRIARY, Richard, J. ,  McCORMICK, Kevin, D. ,  PIWINSKI, John, J. ,  SHIH, Neng-Yang ,  SHUE, Ho-Jane

IPC: C07D403/12 ,  C07D417/14 ,  C07D487/08 ,  C07D401/12 ,  C07D401/14 ,  C07D453/06 ,  C07D471/08 ,  C07D409/12 ,  C07D413/14 ,  C07D451/06 ,  C07D451/04

CPC classification number: C07D451/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D451/06 ,  C07D453/06 ,  C07D471/08 ,  C07D487/08

Abstract: The invention relates to compounds of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc', l and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

Abstract translation: 本发明涉及式（I）的化合物，其中Z，R c，y，m，u，Ar 2，n，X，R c'，l和Ar 2如本文所述。 这些化合物是神经激肽拮抗剂。 这些化合物可用于治疗慢性气道疾病，如哮喘。

公开(公告)号：EP1452527A4

公开(公告)日：2005-11-09

申请号：EP02785933

申请日：2002-11-13

Applicant: SHISEIDO CO LTD

Inventor： HIRUMA TAKUYA ,  KOBAYASHI KOJI ,  INOMATA SHINJI

IPC: A61K8/49 ,  A61K31/403 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/55 ,  A61P1/02 ,  A61P1/04 ,  A61P17/00 ,  A61P17/16 ,  A61P19/02 ,  A61P19/04 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07D209/52 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/14 ,  C07D451/06 ,  C07D453/06 ,  C07D471/08 ,  A61K7/48

CPC classification number: A61Q19/08 ,  A61K8/0212 ,  A61K8/492 ,  A61K31/403 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/55 ,  A61K2800/782 ,  A61Q1/02 ,  A61Q19/00 ,  C07D209/52 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/14 ,  C07D451/06 ,  C07D453/06 ,  C07D471/08

Abstract: An azabicyclo compound (I) or a salt thereof which each has excellent inhibitory activity against matrix metalloproteases (MMPs) and is useful in medicinal compositions, cosmetic compositions, and skin preparations. In the formula (I), R represents hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, COOR1, carbamoyl, or SO2R2 (R1 and R2 each is alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl); X represents methylene, ethylene, or propylene; and …… indicates a single bond or double bond.

公开(公告)号：EP0906297B1

公开(公告)日：2004-02-25

申请号：EP97927017.0

申请日：1997-06-19

Applicant: Université de Liège

Inventor： PIROTTE, Bernard ,  LEBRUN, Philippe ,  De TULLIO, Pascal ,  SOMERS, Fabian ,  DELARGE, Jacques ,  HANSEN, John, Bondo ,  NIELSEN, Flemming, Elmelund ,  HANSEN, Holger, Claus ,  MOGENSEN, John, Patrick ,  TAGMOSE, Tina, Moller

IPC: C07D285/24 ,  C07D417/04 ,  C07D417/12 ,  C07D453/02 ,  C07D453/06 ,  A61K31/54

CPC classification number: A61K31/541 ,  A61K31/5415 ,  C07D285/24 ,  C07D453/02 ,  C07D453/06