- 专利标题： IGG4 FC FRAGMENT COMPRISING MODIFIED HINGE REGION
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申请号： EP14804503.2申请日： 2014-05-29
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公开(公告)号： EP3006455B1公开(公告)日： 2018-07-04
- 发明人: JUNG, Sung Youb , HUH, Yong Ho , PARK, Sung Hee , LEE, Jong Soo , CHOI, In Young
- 申请人： Hanmi Pharm. Co., Ltd.
- 申请人地址： 214 Muha-ro Paltan-myeon Hwaseong-si, Gyeonggi-do 445-958 KR
- 专利权人： Hanmi Pharm. Co., Ltd.
- 当前专利权人： Hanmi Pharm. Co., Ltd.
- 当前专利权人地址： 214 Muha-ro Paltan-myeon Hwaseong-si, Gyeonggi-do 445-958 KR
- 代理机构： Andrews, Robert
- 优先权： KR20130063029 20130531
- 国际公布： WO2014193173 20141204
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; C12N15/13 ; C12N15/63 ; A61K47/42
摘要：
The present invention relates to a modified IgG4 Fc fragment useful as a drug carrier. When the modified IgG4 Fc fragment of the present invention is combined with an arbitrary drug, the resulting drug conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
公开/授权文献
- EP3006455A1 IGG4 FC FRAGMENT COMPRISING MODIFIED HINGE REGION 公开/授权日：2016-04-13
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