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210 条记录 (耗时 0.027 秒)

    SINGLE-STRANDED NUCLEIC ACID FOR DETECTING NUCLEIC ACID OR PROTEIN IN REAL TIME AND DETECTION METHOD USING SAME
    1.
    发明公开
    SINGLE-STRANDED NUCLEIC ACID FOR DETECTING NUCLEIC ACID OR PROTEIN IN REAL TIME AND DETECTION METHOD USING SAME 审中-公开

    公开(公告)号：EP3418393A1

    公开(公告)日：2018-12-26

    申请号：EP17753458.3

    申请日：2017-02-15

    申请人： Nuribio Co., Ltd.

    发明人： NAM, Young Hyean

    IPC分类号： C12Q1/68 ,  G01N33/533

    CPC分类号： C12Q1/68 ,  G01N33/533

    摘要： The present invention relates to a promer that has a structure of X-Y-Z and that comprises a detectable marker attached to both ends or the inside thereof and also that is used as a primer and a probe during real-time detection of nucleic acid or protein, and to a method for real-time detection of nucleic acid, comprising amplifying a nucleic acid to be detected using the promer, and then measuring the amount of fragments of the promer cleaved, or to a method for real-time detection of protein. The method for detection of nucleic acid or protein according to the present invention uses a small amount of oligos compared to a conventional detection method, does not require a separate probe for real-time detection, and thus can achieve real-time detection of the nucleic acid or protein to be detected in a cost-effective and simple manner. Furthermore, mutations in the Y region can be detected through amplification after cleavage of the Y region of the promer, and multiplex detection of nucleic acids or proteins larger than the number of fluorescent labels attached to the promer is possible. Thus, the present invention can be effectively used for diagnosis of various diseases and for prognostic diagnosis.

    METHOD FOR MANUFACTURING MOLDED MEMBER
    3.
    发明公开
    METHOD FOR MANUFACTURING MOLDED MEMBER 审中-公开

    公开(公告)号：EP3409394A1

    公开(公告)日：2018-12-05

    申请号：EP17760153.1

    申请日：2017-03-02

    申请人： Nisshin Steel Co., Ltd.

    发明人： NAKAMURA, Naofumi ,  YAMAMOTO, Yudai

    IPC分类号： B21D22/28 ,  B21D24/10

    CPC分类号： B21D22/28 ,  B21D22/30

    摘要： An object of the present invention is to provide a method for manufacturing a molded member, which can maintain high accuracy circularity of an inner diameter of a tubular body even if a thickness of a base metal sheet varies and which can prevent occurrence of adhesion, seizure of the like of the base metal sheet to a die used for finishing ironing. The base metal sheet is subjected to multi-stage drawing to manufacture the molded member including a tubular body and a flange formed at an end portion of the body. The multi-stage drawing includes: preliminary drawing for forming a preliminary body having a body element from the base metal sheet; at least one compression drawing performed after the preliminary drawing and forming the body by drawing the body element while applying a compressive force to the body element; and at least one finishing ironing performed after the at least one compression drawing to ensure dimensional accuracy.

    MOLDED MATERIAL PRODUCTION METHOD AND MOLDED MATERIAL
    5.
    发明公开
    MOLDED MATERIAL PRODUCTION METHOD AND MOLDED MATERIAL 审中-公开

    公开(公告)号：EP3401033A1

    公开(公告)日：2018-11-14

    申请号：EP17756457.2

    申请日：2017-02-21

    申请人： Nisshin Steel Co., Ltd.

    发明人： NAKAMURA, Naofumi ,  YAMAMOTO, Yudai

    IPC分类号： B21D22/28

    摘要： Provided is a method for producing a molded material by molding processes including at least one drawing-out process and at least one drawing process performed after the drawing-out process, in which a width of a punch 31 used in the drawing-out process on a rear end side is wider than a width of the punch on a distal end side, and an ironing process is performed on a region corresponding to a flange of a base metal sheet 2 by pushing the base metal sheet together with the punch 31 into a pushing hole 30a, and the drawing process is carried out using a die and a drawing sleeve, and processing is performed on a region subjected to the ironing process in the drawing-out process, while maintaining a constant mold gap between the die and the drawing sleeve.

    METHOD AND KIT FOR DIAGNOSING ALZHEIMER'S DISEASE USING G72 PROTEIN AND SLC7A11 MRNA AS BIOMARKERS
    6.
    发明公开
    METHOD AND KIT FOR DIAGNOSING ALZHEIMER'S DISEASE USING G72 PROTEIN AND SLC7A11 MRNA AS BIOMARKERS 审中-公开

    公开(公告)号：EP3361257A1

    公开(公告)日：2018-08-15

    申请号：EP17193573.7

    申请日：2017-09-27

    申请人： Kaohsiung Chang Gung Memorial Hospital

    发明人： LIN, Chieh-Hsin ,  LANE, Hsien-Yuan

    IPC分类号： G01N33/68 ,  C07K14/47

    摘要： A method for diagnosing Alzheimer's disease (AD) includes the steps of: determining a biomarker level in a blood sample from a human subject suspected of having AD, the biomarker level being selected from the group consisting of a G72 protein level, an SLC7A11 mRNA expression level, and a combination thereof; comparing the biomarker level with a predetermined standard therefor; wherein an increase in the biomarker level relative to the predetermined standard therefor is indicative of AD in the human subject. A kit for diagnosing AD includes a material for determining the biomarker level and instructions for using the kit.

    SHUTTLE DEVICE
    8.
    发明公开
    SHUTTLE DEVICE 审中-公开

    公开(公告)号：EP3341085A1

    公开(公告)日：2018-07-04

    申请号：EP16840403.6

    申请日：2016-08-26

    申请人： Safetylink Pty Ltd

    发明人： POLDMAA, Arvo

    IPC分类号： A62B35/00 ,  E04G21/32

    CPC分类号： A62B35/0081 ,  A62B35/0075 ,  E04G21/3261 ,  E04G21/329 ,  E04G21/3295

    摘要： The present invention is directed to a shuttle device for a height safety system, the device including a first member having an inner wall defining a recess, the inner wall terminating at two sides to define a first opening. The device further includes a second member received in the recess of the first member, the second member being slidable relative to the first member to facilitate movement of the device between a locked condition and an unlocked condition. In the locked condition, the second member and a side of the inner wall define a second opening, the second opening being smaller than the first opening.