-
公开(公告)号：EP3616727A1
公开(公告)日：2020-03-04
申请号：EP19197388.2
申请日：2014-02-26
发明人： HWANG, Sang Youn , HUH, Yong Ho , KIM, Jin Young , HONG, Sung Hee , CHOI, In Young , JUNG, Sung Youb , KWON, Se Chang , KIM, Dae Jin , KIM, Hyun Uk , JANG, Myung Hyun , KIM, Seung Su
摘要： The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.
-
公开(公告)号：EP3406627A1
公开(公告)日：2018-11-28
申请号：EP18168489.5
申请日：2014-05-29
发明人： JUNG, Sung Youb , HUH, Yong Ho , PARK, Sung Hee , LEE, Jong Soo , CHOI, In Young
CPC分类号： A61K38/193 , A61K47/60 , A61K47/68 , A61K47/6813 , A61K47/6849 , C07K14/47 , C07K16/2803 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a modified IgG4 Fc fragment useful as a drug carrier. When the modified IgG4 Fc fragment of the present invention is combined with an arbitrary drug, the resulting drug conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
-
公开(公告)号：EP2963056B1
公开(公告)日：2019-11-13
申请号：EP14757629.2
申请日：2014-02-26
-
公开(公告)号：EP3006455B1
公开(公告)日：2018-07-04
申请号：EP14804503.2
申请日：2014-05-29
发明人： JUNG, Sung Youb , HUH, Yong Ho , PARK, Sung Hee , LEE, Jong Soo , CHOI, In Young
CPC分类号： A61K38/193 , A61K47/60 , A61K47/68 , A61K47/6813 , A61K47/6849 , C07K14/47 , C07K16/2803 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a modified IgG4 Fc fragment useful as a drug carrier. When the modified IgG4 Fc fragment of the present invention is combined with an arbitrary drug, the resulting drug conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
-
5.发明公开RECOMBINANT YEAST TRANSFORMANT AND PROCESS FOR PREPARING IMMUNOGLOBULIN FC FRAGMENT EMPLOYING THE SAME 审中-公开重组HEFETRANSFORMANT及其制造方法的免疫球蛋白Fc片段，以
公开(公告)号：EP2951284A1
公开(公告)日：2015-12-09
申请号：EP14746164.4
申请日：2014-02-03
发明人： KIM, Jin-Sun , HUH, Yong Ho , OH, Euh Lim , KIM, Min Young , JUNG, Sung Youb , KWON, Se Chang
CPC分类号： C12N15/815 , C07K16/00 , C07K2317/14 , C07K2317/52 , C12N15/81
摘要： The present invention relates to a transformant prepared by introducing an expression vector comprising a polynucleotide encoding for a human immunoglobulin Fc fragment into
Pichia sp. yeast, a method for producing an immunoglobulin Fc fragment comprising culturing the transformant, and recovering the immunoglobulin Fc fragment from the culture, and an immunoglobulin Fc fragment, prepared by the above method for use as a drug carrier. The transformant is suggested as a solution to the problems associated with the use of
E. coli or animal cells as hosts for producing immunoglobulin Fc fragments useful as drug carriers, so that it can find various applications in the effective and economical production of drugs.-
6.发明公开IGG4 FC FRAGMENT COMPRISING MODIFIED HINGE REGION 有权IGG4-FC-FRAGMENT MIT MODIFIZIERTEM SCHARNIERBEREICH
公开(公告)号：EP3006455A1
公开(公告)日：2016-04-13
申请号：EP14804503.2
申请日：2014-05-29
发明人： JUNG, Sung Youb , HUH, Yong Ho , PARK, Sung Hee , LEE, Jong Soo , CHOI, In Young
CPC分类号： A61K47/48561 , A61K38/193 , A61K47/60 , A61K47/68 , A61K47/6813 , A61K47/6849 , C07K14/47 , C07K16/2803 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a modified IgG4 Fc fragment useful as a drug carrier. When the modified IgG4 Fc fragment of the present invention is combined with an arbitrary drug, the resulting drug conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
摘要翻译： 本发明涉及可用作药物载体的经修饰的IgG4 Fc片段。 当将本发明的修饰的IgG4 Fc片段与任意药物组合时，所得药物缀合物可以使IgG4 Fc的效应子功能和体内IgG的链交换最小化，同时保持体内活性并改善体内的持续时间 药物缀合物。
-
公开(公告)号：EP2963056A1
公开(公告)日：2016-01-06
申请号：EP14757629.2
申请日：2014-02-26
发明人： HWANG, Sang Youn , HUH, Yong Ho , KIM, Jin Young , HONG, Sung Hee , CHOI, In Young , JUNG, Sung Youb , KWON, Se Chang , KIM, Dae Jin , KIM, Hyun Uk , JANG, Myung Hyun , KIM, Seung Su
摘要： The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.
摘要翻译： 本发明涉及胰岛素类似物，其与天然形式相比具有降低的胰岛素滴度和降低的胰岛素受体结合亲和力，以增加胰岛素的血液半衰期，通过连接胰岛素类似物和载体制备的缀合物 ，包含缀合物的长效制剂，以及制备缀合物的方法。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.013 秒)
