发明公开
EP3019200A2 OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
审中-公开
寡核苷酸配体共轭物及其制备方法
- 专利标题： OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
- 专利标题（中）： 寡核苷酸配体共轭物及其制备方法
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申请号： EP14744737.9申请日： 2014-07-11
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公开(公告)号： EP3019200A2公开(公告)日： 2016-05-18
- 发明人: MANOHARAN, Muthiah , NAIR, Jayaprakash, K. , KANDASAMY, Pachamuthu , MATSUDA, Shigeo , KELIN, Alexander, V. , JAYARAMAN, Muthusamy , RAJEEV, Kallanthottathil, G.
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： 300 Third Street Cambridge, MA 02142 US
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： 300 Third Street Cambridge, MA 02142 US
- 代理机构： Müller-Boré & Partner Patentanwälte PartG mbB
- 优先权： US201361845279P 20130711
- 国际公布： WO2015006740 20150115
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; C07H21/00 ; A61P1/16
摘要：
The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.
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