公开(公告)号：EP3919619A1

公开(公告)日：2021-12-08

申请号：EP21157896.8

申请日：2016-07-15

申请人： Alnylam Pharmaceuticals, Inc.

发明人： JADHAV, Vasant ,  MAIER, Martin ,  ZLATEV, Ivan ,  AKINC, Akin ,  RAJEEV, Kallanthottathil G. ,  NAIR, Jayaprakash K. ,  KANDASAMY, Pachamuthu ,  MANOHARAN, Muthiah

IPC分类号： C12N15/113

摘要： The present invention relates to a multi-targeted molecule comprising a first double-stranded siRNA molecule and a second double-stranded siRNA molecule, wherein the first siRNA and the second siRNA are covalently linked to each other, and wherein at least one ligand is conjugated with the multi-targeted molecule.

公开(公告)号：EP2879718A1

公开(公告)日：2015-06-10

申请号：EP13748246.9

申请日：2013-08-06

申请人： Alnylam Pharmaceuticals, Inc.

发明人： JAYAPRAKASH, Narayanannair, K. ,  KELIN, Alexander, V. ,  KANDASAMY, Pachamuthu ,  KALLANTHOTTATHIL, Rajeev, G. ,  MANOHARAN, Muthiah

IPC分类号： A61K47/48 ,  A61K31/7088

CPC分类号： A61K47/48092 ,  A61K31/7088 ,  A61K47/549 ,  C07C231/14 ,  C07D207/12 ,  C07H1/00 ,  C07H15/26 ,  C12N15/113 ,  C12N2310/351 ,  C12N2320/32

摘要： This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

公开(公告)号：EP4039278A1

公开(公告)日：2022-08-10

申请号：EP22162215.2

申请日：2014-07-11

申请人： Alnylam Pharmaceuticals, Inc.

发明人： MANOHARAN, Muthiah ,  NAIR, Jayaprakash, K. ,  KANDASAMY, Pachamuthu ,  MATSUDA, Shigeo ,  KELIN, Alexander, V. ,  JAYARAMAN, Muthusamy ,  RAJEEV, Kallanthottathil, G.

IPC分类号： A61K47/54 ,  C07H21/00 ,  A61P1/16 ,  C12N15/11

摘要： The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents). The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.

公开(公告)号：EP4253395A3

公开(公告)日：2023-11-29

申请号：EP23175013.4

申请日：2013-08-06

申请人： Alnylam Pharmaceuticals, Inc.

发明人： JAYAPRAKASH, Narayanannair, K. ,  KELIN, Alexander, V. ,  KANDASAMY, Pachamuthu ,  KALLANTHOTTATHIL, Rajeev, G. ,  MANOHARAN, Muthiah

IPC分类号： A61K47/54 ,  A61K31/7088 ,  C07D207/12 ,  C07H1/00 ,  C07H15/26

摘要： This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

公开(公告)号：EP3324980A1

公开(公告)日：2018-05-30

申请号：EP16828302.6

申请日：2016-07-15

申请人： Alnylam Pharmaceuticals, Inc.

发明人： JADHAV, Vasant ,  MAIER, Martin ,  ZLATEV, Ivan ,  AKINC, Akin ,  RAJEEV, Kallanthottathil G. ,  NAIR, Jayaprakash K. ,  KANDASAMY, Pachamuthu ,  MANOHARAN, Muthiah

IPC分类号： A61K31/713 ,  C07H21/02 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K47/549 ,  A61K47/55 ,  C07H21/00 ,  C12N15/111 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2320/31

摘要： The present invention relates, in general to, compounds, compositions and methods useful for modulating gene expression of multiple target nucleic acids by a single chemical entity.

公开(公告)号：EP4253395A2

公开(公告)日：2023-10-04

申请号：EP23175013.4

申请日：2013-08-06

申请人： Alnylam Pharmaceuticals, Inc.

发明人： JAYAPRAKASH, Narayanannair, K. ,  KELIN, Alexander, V. ,  KANDASAMY, Pachamuthu ,  KALLANTHOTTATHIL, Rajeev, G. ,  MANOHARAN, Muthiah

IPC分类号： C07H15/26

摘要： This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

公开(公告)号：EP3019200A2

公开(公告)日：2016-05-18

申请号：EP14744737.9

申请日：2014-07-11

申请人： Alnylam Pharmaceuticals, Inc.

发明人： MANOHARAN, Muthiah ,  NAIR, Jayaprakash, K. ,  KANDASAMY, Pachamuthu ,  MATSUDA, Shigeo ,  KELIN, Alexander, V. ,  JAYARAMAN, Muthusamy ,  RAJEEV, Kallanthottathil, G.

IPC分类号： A61K47/48 ,  C07H21/00 ,  A61P1/16

CPC分类号： C12N15/113 ,  A61K47/48092 ,  A61K47/549 ,  C07H21/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2330/30

摘要： The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.

摘要翻译： 本发明涉及寡核苷酸的配体缀合物（例如，iRNA试剂）及其制备方法。 配体主要来源于单糖。这些缀合物可用于体内递送寡核苷酸。