发明公开
- 专利标题： MODIFIED PSEUDOMONAS EXOTOXIN A
- 专利标题（中）： 改性剂PSEUDOMONAS-EXOTOXIN A
-
申请号： EP14789449.7申请日： 2014-10-03
-
公开(公告)号： EP3038641A2公开(公告)日： 2016-07-06
- 发明人: PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , LEE, Byungkook , NIEDERFELLNER, Gerhard , IMHOF-JUNG, Sabine , BRINKMANN, Ulrich , SCHEUER, Werner , GEORGES, Guy
- 申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , F. Hoffmann-La Roche AG
- 申请人地址： Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, MD 20892-7660 US
- 专利权人： The United States of America, as represented by The Secretary, Department of Health and Human Services,F. Hoffmann-La Roche AG
- 当前专利权人： The United States of America, as represented by The Secretary, Department of Health and Human Services,F. Hoffmann-La Roche AG
- 当前专利权人地址： Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, MD 20892-7660 US
- 代理机构： Huenges, Martin
- 优先权： US201361887418P 20131006; US201361908464P 20131125; US201461982051P 20140421; US201462052665P 20140919
- 国际公布： WO2015051199 20150409
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07K14/21 ; C07K16/12
摘要：
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
公开/授权文献
- EP3038641B1 MODIFIED PSEUDOMONAS EXOTOXIN A 公开/授权日：2019-04-17
信息查询
IPC分类:
