公开(公告)号：EP3038641B1

公开(公告)日：2019-04-17

申请号：EP14789449.7

申请日：2014-10-03

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services ,  F. Hoffmann-La Roche AG

发明人： PASTAN, Ira H. ,  MAZOR, Ronit ,  ONDA, Masanori ,  LEE, Byungkook ,  NIEDERFELLNER, Gerhard ,  IMHOF-JUNG, Sabine ,  BRINKMANN, Ulrich ,  GEORGES, Guy

IPC分类号： C07K14/21 ,  A61K38/00 ,  A61K39/395 ,  C07K16/30 ,  A61K47/68 ,  A61K38/16 ,  C07K16/12 ,  A61K39/00 ,  C07K16/40 ,  A61K31/337

公开(公告)号：EP3038641A2

公开(公告)日：2016-07-06

申请号：EP14789449.7

申请日：2014-10-03

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services ,  F. Hoffmann-La Roche AG

发明人： PASTAN, Ira H. ,  MAZOR, Ronit ,  ONDA, Masanori ,  LEE, Byungkook ,  NIEDERFELLNER, Gerhard ,  IMHOF-JUNG, Sabine ,  BRINKMANN, Ulrich ,  SCHEUER, Werner ,  GEORGES, Guy

IPC分类号： A61K38/16 ,  C07K14/21 ,  C07K16/12

CPC分类号： C07K16/30 ,  A61K31/337 ,  A61K38/00 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6871 ,  A61K2039/505 ,  C07K14/21 ,  C07K16/1214 ,  C07K16/303 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/50 ,  C07K2319/55 ,  A61K2300/00

摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.

摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 本发明还提供了哺乳动物治疗或预防癌症的方法，抑制靶细胞生长的方法，生产PE的方法和嵌合分子的制备方法。

公开(公告)号：EP3231812B1

公开(公告)日：2020-03-25

申请号：EP17163568.3

申请日：2012-06-07

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： PASTAN, Ira H. ,  MAZOR, Ronit ,  ONDA, Masanori ,  VASSALL, Aaron ,  BEERS, Richard ,  EBERLE, Jaime ,  LIU, Wenhai

IPC分类号： C07K14/21 ,  A61K38/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  C07K16/28

公开(公告)号：EP2718308A1

公开(公告)日：2014-04-16

申请号：EP12727074.2

申请日：2012-06-07

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： PASTAN, Ira H. ,  MAZOR, Ronit ,  ONDA, Masanori ,  VASSALL, Aaron ,  BEERS, Richard ,  EBERLE, Jaime ,  LIU, Wenhai

IPC分类号： C07K14/21 ,  A61K38/16

CPC分类号： C07K14/21 ,  A61K38/00 ,  C07K16/2896 ,  C07K2319/33 ,  C07K2319/55

摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.

公开(公告)号：EP4448566A1

公开(公告)日：2024-10-23

申请号：EP22854336.9

申请日：2022-12-16

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： PASTAN, Ira H. ,  ONDA, Masanori ,  HO, Mitchell ,  LIU, Xiu-fen ,  BERA, Tapan ,  CHAKRABORTY, Anirban

IPC分类号： C07K16/18 ,  C07K16/30 ,  C07K14/825 ,  A61P35/00

公开(公告)号：EP3231812A1

公开(公告)日：2017-10-18

申请号：EP17163568.3

申请日：2012-06-07

申请人： The United States of America, as Represented by the Secretary Department of Health and Human Services

发明人： PASTAN, Ira H. ,  MAZOR, Ronit ,  ONDA, Masanori ,  VASSALL, Aaron ,  BEERS, Richard ,  EBERLE, Jaime ,  LIU, Wenhai

IPC分类号： C07K14/21 ,  A61K38/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  C07K16/28

摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.

摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明进一步提供了相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 本发明进一步提供了治疗或预防哺乳动物癌症的方法，抑制靶细胞生长的方法，生产PE的方法以及生产嵌合分子的方法。

公开(公告)号：EP2718308B1

公开(公告)日：2017-05-17

申请号：EP12727074.2

申请日：2012-06-07

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： PASTAN, Ira H. ,  MAZOR, Ronit ,  ONDA, Masanori ,  VASSALL, Aaron ,  BEERS, Richard ,  EBERLE, Jaime ,  LIU, Wenhai

IPC分类号： C07K14/21 ,  A61K38/16

CPC分类号： C07K14/21 ,  A61K38/00 ,  C07K16/2896 ,  C07K2319/33 ,  C07K2319/55

摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.

摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 本发明还提供了哺乳动物治疗或预防癌症的方法，抑制靶细胞生长的方法，生产PE的方法和嵌合分子的制备方法。

公开(公告)号：EP1567556A2

公开(公告)日：2005-08-31

申请号：EP03796552.2

申请日：2003-12-01

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： PASTAN, Ira ,  ONDA, Masanori ,  CHEUNG, Nai-Kong

IPC分类号： C07K16/00 ,  C12P21/08 ,  C07H21/04 ,  A61K39/395

CPC分类号： C07K16/30 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/21 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2319/00

摘要： Immunotoxins are disclosed that include a toxin, a variable region of a heavy chain of a monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9, and a variable region of a light chain of the monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9 and effector molecule. These immunotoxins include scFv and dsFv of monoclonal antibody 8H9. The immunotoxins are of use for the treatment of tumors.