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公开(公告)号：EP3038641A2
公开(公告)日：2016-07-06
申请号：EP14789449.7
申请日：2014-10-03
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , F. Hoffmann-La Roche AG
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , LEE, Byungkook , NIEDERFELLNER, Gerhard , IMHOF-JUNG, Sabine , BRINKMANN, Ulrich , SCHEUER, Werner , GEORGES, Guy
CPC分类号： C07K16/30 , A61K31/337 , A61K38/00 , A61K39/39558 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6871 , A61K2039/505 , C07K14/21 , C07K16/1214 , C07K16/303 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/55 , A61K2300/00
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 本发明还提供了哺乳动物治疗或预防癌症的方法，抑制靶细胞生长的方法，生产PE的方法和嵌合分子的制备方法。
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公开(公告)号：EP2567234B1
公开(公告)日：2018-09-19
申请号：EP11723891.5
申请日：2011-05-09
发明人： DOBOSZ, Michael , SCHEUER, Werner
IPC分类号： A61K49/00 , C07K16/32 , A61K39/00 , G01N33/566 , C07K16/42 , C07K16/18 , G01N33/574 , C07K16/28
CPC分类号： G01N33/566 , A61K49/0032 , A61K49/0058 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K16/4291 , G01N33/57484 , G01N33/57492
摘要： The present invention provides an ex vivo method for detecting a subset of cells with a specific binding domain, the binding domain, diagnostic compositions comprising the binding domain, and kits comprising the binding domain.
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公开(公告)号：EP3083696B1
公开(公告)日：2018-02-14
申请号：EP14821603.9
申请日：2014-12-18
发明人： CROASDALE, Rebecca , DUERNER, Lydia Jasmin , GEORGES, Guy , HOFER, Thomas , HOSSE, Ralf , KLEIN, Christian , MOESSNER, Ekkehard , MOSER, Samuel , SCHAEFER, Wolfgang , SCHANZER, Juergen Michael , SCHEUER, Werner , SUSTMANN, Claudio , UMANA, Pablo
IPC分类号： C07K16/32 , C07K16/46 , A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：EP2344537A1
公开(公告)日：2011-07-20
申请号：EP09736830.2
申请日：2009-10-07
发明人： BAEHNER, Monika , BRINKMANN, ULRICH , GEORGES, Guy , GRIEP, Remko, Albert , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , SEEBER, Stefan , THOMAS, Markus
IPC分类号： C07K16/22 , A61K39/395 , C07K19/00 , C07K16/46 , C07K14/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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5.发明公开CONJUGATES OF THE C DOMAIN OF HUMAN GELATINASE A AND POLYETHYLENE GLYCOL, METHODS OF PURIFICATION AND USES THEREOF 审中-公开C结构域人的缀合物和明胶酶A聚乙二醇，清洗方法和用途
公开(公告)号：EP1482982A1
公开(公告)日：2004-12-08
申请号：EP03743362.0
申请日：2003-02-28
CPC分类号： C12N9/6491 , A61K38/4886 , A61K47/60
摘要： A conjugate comprising the C domain of human gelatinase A (PEX domain, PEX) and one to three poly(ethylene glycol) groups), said poly(ethylene glycol) group(s) having an overall molecular weight of from about 10 to 40 kDa and being conjugated via primary amino group(s) of said PEX is useful for the treatment of cancer.
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6.发明公开NUCLEIC ACIDS ENCODING CD40/CD40L CHIMERIC POLYPEPTIDES, METHODS FOR THEIR PRODUCTION AND USES THEREOF 审中-公开NUKLEOTIDENSÄURE编码CD40 / CD40L嵌合多肽，方法生产及其用途
公开(公告)号：EP1173589A1
公开(公告)日：2002-01-23
申请号：EP00918873.1
申请日：2000-04-13
发明人： DICKER, Frank , FRIESS, Thomas , MAASS, Gerd , PESSARA, Ulrich , SCHEUER, Werner , SEEBER, Stefan
IPC分类号： C12N15/62 , C07K14/705 , C07K19/00 , C12N5/10 , A61K48/00
CPC分类号： C07K14/70578 , A61K38/00 , A61K48/00
摘要： A nucleic acid encoding a chimeric polypeptide comprising nucleic acid fragments encoding i) a mammalian signal peptide and downstream thereof, ii) the binding and trimerization domain of CD40L and downstream thereof, iii) a spacer of 50 to 100 amino acids and downstream thereof, iv) the transmembrane and signal transduction domains of CD40, is useful as a gene therapy agent for the local treatment of solid tumors.
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公开(公告)号：EP2552960B1
公开(公告)日：2018-04-18
申请号：EP11711071.8
申请日：2011-03-24
发明人： BAEHNER, Monika , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , STUBENRAUCH, Kay-Gunnar , THOMAS, Markus
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：EP2056874A1
公开(公告)日：2009-05-13
申请号：EP07786693.7
申请日：2007-08-17
发明人： FRIESS, Thomas , HASMANN, Max , SCHEUER, Werner
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/545 , C07K2317/76 , C07K2317/92
摘要： The present invention provides a method of treating a patient suffering from relapsed HER2 positive cancer with an anti-VEGF antibody during or after treatment with an anti-HER2 antibody. The invention also provides corresponding articles of manufacture.
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公开(公告)号：EP2331145B1
公开(公告)日：2014-12-17
申请号：EP09814096.5
申请日：2009-09-21
IPC分类号： A61K49/00
CPC分类号： A61K49/0008 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/545 , C07K16/32
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公开(公告)号：EP2344537B1
公开(公告)日：2014-01-29
申请号：EP09736830.2
申请日：2009-10-07
发明人： BAEHNER, Monika , BRINKMANN, Ulrich , GEORGES, Guy , GRIEP, Remko Albert , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen Michael , SCHEUER, Werner , SEEBER, Stefan , THOMAS, Markus
IPC分类号： C07K16/22 , A61K39/395 , C07K19/00 , C07K16/46 , C07K14/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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