发明公开
EP3053601A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER, CONTAINING CYB5R3 GENE OR PROTEIN AS ACTIVE INGREDIENT
有权
用于预防的药物组合物和治疗癌症与CYB5R3基因或蛋白为活动
- 专利标题： PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER, CONTAINING CYB5R3 GENE OR PROTEIN AS ACTIVE INGREDIENT
- 专利标题（中）： 用于预防的药物组合物和治疗癌症与CYB5R3基因或蛋白为活动
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申请号： EP14851311.2申请日： 2014-09-30
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公开(公告)号： EP3053601A1公开(公告)日： 2016-08-10
- 发明人: WON, Mi Sun , BAN, Hyun Seung , KIM, Bo Kyung , NAM, Soon Woo , LEE, Kyeong , LEE, Young-Ju , LEE, Hong-Sub , KIM, Dong Uk , PARK,Ki Cheol , OH, Kyoung-Jin , IM, Joo-Young
- 申请人： Korea Research Institute of Bioscience and Biotechnology
- 申请人地址： 125 Gwahak-ro Yuseong-gu Daejeon 305-806 KR
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： 125 Gwahak-ro Yuseong-gu Daejeon 305-806 KR
- 代理机构： Office Freylinger
- 优先权： KR20130117527 20131001
- 国际公布： WO2015050364 20150409
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K38/17 ; A61K38/16 ; A61P35/00 ; C12N9/02 ; A61K38/44
摘要：
The present invention relates to a pharmaceutical composition for preventing and treating cancer, containing cytochrome b5 reductase 3 (cyb5R3) protein as an active ingredient. The expression of hypoxia-inducible factor-1 (HIF-1) is significantly reduced in cancer cells over-expressing cyb5R3 so as to inhibit the growth of cancer cells and effectively inhibit in vivo tumor growth and metastasis, and thus the cyb5R3 gene or protein of the present invention can be useful as an active ingredient of a pharmaceutical composition for preventing and treating cancer.
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