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公开(公告)号：EP4375292A1
公开(公告)日：2024-05-29
申请号：EP22846274.3
申请日：2022-07-21
发明人： KIM, Tae-Don , LEE, Sooyun
IPC分类号： C07K14/705 , C07K16/28 , C07K16/32 , A61P35/00 , A61K35/17
CPC分类号： C07K14/705 , C07K16/32 , C07K16/28 , A61P35/00 , A61K2239/2920230501 , A61K39/464406 , C12N5/0646 , A61K2239/2220230501 , A61K39/4646 , C12N5/0636 , A61K39/4613 , A61K39/4631 , A61K39/464404 , A61K39/464422
摘要： The present invention relates to: a novel chimeric antigen receptor containing, as an intracellular signaling domain, an intracellular domain of a receptor containing a dead region; and immune cells expressing the chimeric antigen receptor. In environments in which normal cells are present, the immune cells expressing the chimeric antigen receptor according to the present invention exhibit little or no cytotoxicity and cell death of the immune cells is exhibited, thus ensuring the stability of the normal cells. Conversely, in environments in which target cells are present, the immune cells exhibit more potent cytotoxicity than with conventional techniques utilizing a lone chimeric antigen receptor.
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公开(公告)号：EP3737763A1
公开(公告)日：2020-11-18
申请号：EP19739135.2
申请日：2019-01-09
发明人： KWON, Ki-Sun , LEE, Kwang-Pyo , SHIN, Yeo Jin , LEE, Bora , LEE, Seung Min
IPC分类号： C12N15/113 , C12Q1/6883
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公开(公告)号：EP3725320A1
公开(公告)日：2020-10-21
申请号：EP18889101.4
申请日：2018-12-12
发明人： KIM, Byoung Chan , KIM, Kyoung Shim , LEE, Chul Ho , CHANG, Dong Ho , KIM, Yong-Hoon , NOH, Jung-Ran , CHOI, Dong Hui , HWANG, Jung Hwan , GO, Jun , KIM, Jaehun , PARK, Hye-Yeon , SEO, Yun-Jung , RYU, Young-Kyoung , LEE, In-Bok , CHOI, Young Keun , CHOI, Jung-Hyeon
IPC分类号： A61K35/66 , A23L33/135 , A23K10/16
摘要： The present invention relates to an Agathobaculum sp. strain having prophylactic or therapeutic effects on autism spectrum disorders, and use thereof. When the intestinal microorganism Agathobaculum sp. strain of the present invention was orally administered to valproic acid (VPA)-induced autism model mice and BTBR autism model mice, the effects of remarkably improving autism spectrum disorders including repetitive behaviors, hyperactivity, social deficiency and cognitive/memory dysfunction of the mice were observed, as compared with a non-treated control. Accordingly, it may be usefully applied to foods, drugs, or feeds for preventing or treating autism spectrum disorders, and thus is very useful in the relevant industries.
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公开(公告)号：EP3321379B1
公开(公告)日：2020-09-16
申请号：EP17200547.2
申请日：2017-11-08
申请人： Republic of Korea Management: Rural Development Administration , Korea Research Institute of Bioscience and Biotechnology , Jeju National University Industry-Academic Cooperation
IPC分类号： C12Q1/6888 , A01K67/02
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公开(公告)号：EP3378940B1
公开(公告)日：2020-06-03
申请号：EP16860244.9
申请日：2016-10-27
发明人： AHN, Jung Oh , LEE, Hong Weon , JANG, Min Jeong , KIM, Chun Sug , PARK, Gyu Yeon
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公开(公告)号：EP2769973B1
公开(公告)日：2018-09-12
申请号：EP12841496.8
申请日：2012-09-28
发明人： OH, Sei Ryang , KIM, Jae Wha , LEE, Hyeong Kyu , KHIEV, Piseth , KIM, Doo Young , KIM, Jung Hee , SONG, Jae Sung , AHN, Kyung Seop
IPC分类号： C07C69/716 , C07C69/013 , A61P31/12 , A61K31/22
摘要： The present invention relates to an injenane-type diterpene compound derived from Euphorbia kansui Liou, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the injenane-type diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.
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7.发明授权PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ASTHMA COMPRISING PISTACIA WEINMANNIFOLIA J. POISS. EX FRANCH EXTRACT OR FRACTION THEREOF 有权用于预防或治疗包含内脏的哮喘的药物组合物Weinmnicifolia J.Poiss。 EX FRANCH EXTRACT或其部分
公开(公告)号：EP3025721B1
公开(公告)日：2018-05-02
申请号：EP14819875.7
申请日：2014-07-01
发明人： AHN, Kyung Seop , OH, Sei Ryang , KWON, Ok Kyoung , SHIN, In Sik , RYU, Hyung Won , LEE, Sang Woo , LEE, Joong Ku , LEE, Hyeong Kyu , CHOI, Sang Ho , KIM, Doo Young , KIM, Jung Hee , LI, Wan Yi , JIN, Hang
CPC分类号： A61K36/22 , A23L33/105 , A23V2002/00 , A61K2236/33
摘要： The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.
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8.发明授权PHORBOL TYPE DITERPENE COMPOUND, PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF VIRAL INFECTIOUS DISEASES INCLUDING SAME 有权PHORBOL型二萜化合物，用于治疗或预防病毒感染性疾病的药物组合物，包括相同的
公开(公告)号：EP2792666B1
公开(公告)日：2018-04-25
申请号：EP12842971.9
申请日：2012-09-28
发明人： OH, Sei Ryang , KIM, Jae Wha , PEI, Yi Hua , LEE, Hyeong Kyu , KANG, Ho Bum , KIM, Doo Young , AHN, Kyung Seop , JI, Da Chung
IPC分类号： C07C69/738 , C07C69/013 , A61K31/015
CPC分类号： C07C69/753 , A23L33/00 , A23V2002/00 , A61K31/215 , C07C69/33 , C07C2603/40
摘要： The present invention relates to a diterpene compound derived from Aleurites fordii, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.
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9.发明授权WATER-SOLUBLE FLUORESCENT FULLERENE DERIVATIVE, AND PREPARATION METHOD THEREOF 有权水溶性荧光FULLERENE衍生物，及其制备方法
公开(公告)号：EP2565248B1
公开(公告)日：2017-11-08
申请号：EP11775226.1
申请日：2011-04-25
发明人： CHUNG, Bong Hyun , JEONG, Jin Young
CPC分类号： C07C41/06 , B82Y30/00 , C07C2604/00 , C09K11/06 , C09K2211/1011 , Y10S977/74 , Y10S977/847 , C07C43/196
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10.发明公开Pharmaceutical composition for prevention or treatment neuro-inflammation or neurodegenerative diseases comprising Portulaca grandiflora Hook. extracts or fractions thereof 审中-公开用于预防或治疗神经炎症或神经退行性疾病的药物组合物，包含马齿苋Hook。 提取物或其部分
公开(公告)号：EP3189846A1
公开(公告)日：2017-07-12
申请号：EP15835563.6
申请日：2015-08-27
申请人： Research & Business Foundation Sungkyunkwan University , Korea Research Institute of Bioscience and Biotechnology
发明人： JANG, Choon Gon , KWON, Seung Hwan , CHOI, Sang Ho , LI, Wan Yi , OH, Sei-Ryang , LEE, Sang-Woo , JIN, Hang , RYU, Hyung Won
IPC分类号： A61K36/185 , A61P25/28 , A61P25/16
CPC分类号： A61K36/185 , A61K2236/33 , A61P25/16 , A61P25/28
摘要： The present invention relates to a pharmaceutical composition and a food composition containing Portulaca grandiflora Hook. extract or a fraction thereof as an active ingredient for preventing, treating or ameliorating neuroinflammation or neuro-degenerative diseases. The Portulaca grandiflora Hook. extract or a fraction thereof according to the present invention is derived from a natural product which has been in use as a natural medicinal ingredient, and as such, has no side effects and inhibits expression of NO, PGE 2 , iNOS and/or COX-2 genes or protein, which are factors associated with inflammation, and is additionally superbly effective for increasing and improving memory and the ability to learn, and thus can be beneficially used to prevent or treat neuroinflammation or neuro-degenerative diseases.
摘要翻译： 本发明涉及一种药物组合物和含有马齿苋钩的食物组合物。 提取物或其部分作为用于预防，治疗或改善神经炎症或神经退行性疾病的活性成分。 马齿苋钩。 根据本发明的提取物或其部分来源于已经用作天然药物成分的天然产物，因此没有副作用并且抑制NO，PGE2，iNOS和/或COX-2的表达 基因或蛋白质，它们是与炎症相关的因子，并且对于增加和改善记忆和学习能力另外是非常有效的，因此可以有益地用于预防或治疗神经炎症或神经退行性疾病。
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