发明公开
- 专利标题: PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS
- 专利标题(中): 吡啶二酮羟基苯甲酸酯
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申请号: EP14852720.3申请日: 2014-10-09
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公开(公告)号: EP3055299A1公开(公告)日: 2016-08-17
- 发明人: YANG, Min , TAMANG, David, Lee , JONES, Simon, Stewart , MAZITSCHEK, Ralph , VAN DUZER, John, H.
- 申请人: Acetylon Pharmaceuticals, Inc.
- 申请人地址: 70 Fargo Street, Suite 205 Boston, MA 02210 US
- 专利权人: Acetylon Pharmaceuticals, Inc.
- 当前专利权人: Acetylon Pharmaceuticals, Inc.
- 当前专利权人地址: 70 Fargo Street, Suite 205 Boston, MA 02210 US
- 代理机构: Harris, Jennifer Lucy
- 优先权: US201361889295P 20131010; US201461944754P 20140226; US201461979694P 20140415
- 国际公布: WO2015054474 20150416
- 主分类号: C07D401/12
- IPC分类号: C07D401/12 ; C07D401/14 ; C07D409/14 ; C07D239/42 ; A61K31/506 ; A61P35/00
摘要:
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDACl, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDACl, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.
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