公开(公告)号：EP3076973A1

公开(公告)日：2016-10-12

申请号：EP14867332.0

申请日：2014-12-03

申请人： Acetylon Pharmaceuticals, Inc.

发明人： QUAYLE, Steven, Norman ,  JONES, Simon, Stewart

IPC分类号： A61K31/505 ,  A61K31/495 ,  A61K31/16 ,  A61P37/00

CPC分类号： A61K31/505 ,  A61K31/4439 ,  A61K31/454 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to combinations comprising an HDAC inhibitor and an immunomodulatory drug for the treatment of lymphoma in a subject in need thereof. Also provided herein are methods for treating lymphoma in a subject in need thereof comprising administering to the subject an effective amount of one of the above combinations.

公开(公告)号：EP3055299A1

公开(公告)日：2016-08-17

申请号：EP14852720.3

申请日：2014-10-09

申请人： Acetylon Pharmaceuticals, Inc.

发明人： YANG, Min ,  TAMANG, David, Lee ,  JONES, Simon, Stewart ,  MAZITSCHEK, Ralph ,  VAN DUZER, John, H.

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D239/42 ,  A61K31/506 ,  A61P35/00

CPC分类号： A61K31/506 ,  A61K31/505 ,  A61K31/5377 ,  A61K45/06 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D417/12

摘要： Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDACl, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDACl, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.

摘要翻译： 本文提供了化合物，包含这些化合物的药物组合物，以及使用这些化合物治疗或预防与HDAC活性相关的疾病或病症的方法，特别是涉及HDAC1，HDAC2和/或HDAC6的活性的疾病或病症。 本文还提供了抑制神经母细胞瘤细胞迁移，诱导成神经细胞瘤细胞和改变神经母细胞瘤细胞的细胞周期进程的方法，包括向细胞施用治疗有效量的HDAC1，HDAC2和/或HDAC6选择性抑制剂 或其药学上可接受的盐。