发明公开
EP3066118A2 ALK ANTIBODIES, CONJUGATES, AND CHIMERIC ANTIGEN RECEPTORS, AND THEIR USE
审中-公开
ALK抗体偶联物及其嵌合抗原受体及其用途
- 专利标题： ALK ANTIBODIES, CONJUGATES, AND CHIMERIC ANTIGEN RECEPTORS, AND THEIR USE
- 专利标题（中）： ALK抗体偶联物及其嵌合抗原受体及其用途
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申请号： EP14805427.3申请日： 2014-11-06
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公开(公告)号： EP3066118A2公开(公告)日： 2016-09-14
- 发明人: ORENTAS, Rimas , MACKALL, Crystal
- 申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 申请人地址： Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325, MSC 7660 Bethesda, MD 20892-7660 US
- 专利权人： The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325, MSC 7660 Bethesda, MD 20892-7660 US
- 代理机构： Gowshall, Jonathan Vallance
- 优先权： US201361900806P 20131106
- 国际公布： WO2015069922 20150514
- 主分类号： C07K14/725
- IPC分类号： C07K14/725 ; C07K16/30 ; C07K16/46
摘要：
Chimeric antigen receptors that specifically bind to anaplastic lymphoma kinase are disclosed. Nucleic acids, recombinant expression vectors, host cells, antibodies, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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