- 专利标题： STEREO-SPECIFIC SYNTHESIS OF (13R)-MANOYL OXIDE
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申请号： EP14816252.2申请日： 2014-12-19
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公开(公告)号： EP3083975B1公开(公告)日： 2018-11-14
- 发明人: HAMBERGER, Björn , PATERAKI, Eirini , MØLLER, Birger Lindberg , NØRHOLM, Morten , NIELSEN, Morten Thrane , ANDERSEN-RANBERG, Johan , BOHLMANN, Carl Jörg , ZERBE, Philipp
- 申请人： Technical University of Denmark , University of Copenhagen
- 申请人地址： Anker Engelundsvej 1 Bygning 101A 2800 Kgs. Lyngby DK
- 专利权人： Technical University of Denmark,University of Copenhagen
- 当前专利权人： Technical University of Denmark,University of Copenhagen
- 当前专利权人地址： Anker Engelundsvej 1 Bygning 101A 2800 Kgs. Lyngby DK
- 代理机构： Rees, Kerry
- 优先权： EP13198742 20131220; EP13198756 20131220
- 国际公布： WO2015091943 20150625
- 主分类号： C12P17/02
- IPC分类号： C12P17/02 ; C07D311/00 ; C12N9/16 ; C12N15/52
摘要：
The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.
公开/授权文献
- EP3083975A1 STEREO-SPECIFIC SYNTHESIS OF (13R)-MANOYL OXIDE 公开/授权日：2016-10-26
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