发明公开
EP3092230A4 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
有权
INHIBITOREN DES RENALEN KALIUMKANALS DERÄUSSERENMEDULLA
- 专利标题： INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
- 专利标题（中）： INHIBITOREN DES RENALEN KALIUMKANALS DERÄUSSERENMEDULLA
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申请号： EP15735293申请日： 2015-01-05
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公开(公告)号： EP3092230A4公开(公告)日： 2017-06-14
- 发明人: BISWAS DIPSHIKHA , DING FA-XIANG , DONG SHUZHI , GU XIN , JIANG JINLONG , PASTERNAK ALEXANDER , SUZUKI TAKAO , VACCA JOSEPH , XU SHOUNING
- 申请人： MERCK SHARP & DOHME
- 专利权人： MERCK SHARP & DOHME
- 当前专利权人： MERCK SHARP & DOHME
- 优先权： CN2014070384 2014-01-09
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; A61K31/4439 ; A61K31/497 ; A61K31/506 ; A61P9/00 ; A61P9/10 ; C07D405/06 ; C07D487/10
摘要：
The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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