发明公开
- 专利标题： BENZIMIDAZOL-2-AMINES AS MIDH1 INHIBITORS
- 专利标题（中）： 苯并咪唑-2-胺作为MIDH1抑制剂
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申请号： EP15705936.1申请日： 2015-02-10
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公开(公告)号： EP3105210A1公开(公告)日： 2016-12-21
- 发明人: REHWINKEL, Hartmut , SIEBENEICHER, Holger , ANLAUF, Sonja , NGUYEN, Duy , PANKNIN, Olaf , RING, Sven , SCHWEDE, Wolfgang , BAUSER, Marcus , ZIMMERMANN, Katja , KAULFUSS, Stefan , NEUHAUS, Roland
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： BIP Patents
- 优先权： EP14154680 20140211; EP14182001 20140822
- 国际公布： WO2015121209 20150820
- 主分类号： C07D235/30
- IPC分类号： C07D235/30 ; A61K31/4184 ; A61P35/00
摘要：
The present invention relates to benzimidazol-2-amines of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
公开/授权文献
- EP3105210B1 BENZIMIDAZOL-2-AMINES AS MIDH1 INHIBITORS 公开/授权日：2019-01-30
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