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公开(公告)号：EP3126337A2
公开(公告)日：2017-02-08
申请号：EP15741893.0
申请日：2015-04-01
发明人： EIS, Knut , ACKERSTAFF, Jens , WAGNER, Sarah , BASTING, Daniel , GOLZ, Stefan , BENDER, Eckhard , LI, Volkhart Min-Jian , LIENAU, Philip , LIU, Ningshu , SIEGEL, Franziska , BAUSER, Marcus , SÜLZLE, Detlev , HOLTON, Simon , BAIRLEIN, Michaela , BUCHGRABER, Philipp , BÁLINT, József
IPC分类号： C07D233/90 , A61K31/4164 , A61K31/4439 , C07D401/12 , C07D263/34 , A61K31/421 , A61K31/496 , C07D403/12 , C07D295/092 , C07D413/06 , A61K31/5377 , A61K31/454 , A61P35/00 , C07D491/107 , A61P35/02
CPC分类号： A61K31/541 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5355 , A61K45/06 , C07D233/90 , C07D263/34 , C07D295/092 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D487/10 , C07D491/107
摘要： The present invention relates to amido-substituted azole compounds of general formula (I), in which X1, X2, R1, R2, R4, R5, R7 and R8 are as defined in the claims which are inhibitors of TNKS1 and/or TNKS2, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的酰胺取代的唑化合物，其中X 1，X 2，R 1，R 2，R 4，R 5，R 7和R 8如权利要求中所定义，它们是TNKS1和/或TNKS2的抑制剂， 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及用于制备用于治疗或预防疾病，特别是赘生物的药物组合物的所述化合物的用途， 作为唯一的药剂或与其它活性成分组合。
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公开(公告)号：EP2167499B1
公开(公告)日：2011-12-14
申请号：EP08773422.4
申请日：2008-06-13
发明人： ALLERHEILIGEN, Swen , BAUSER, Marcus , SCHIROK, Hartmut , HÄRTER, Michael , SIEGEL, Stephan , RESTER, Ulrich , GERDES, Christoph , HEITMEIER, Stefan , VON DEGENFELD, Georges , BUCHMÜLLER, Anja , DITTRICH-WENGENROTH, Elke , SAATMANN, Uwe , STRASSBURGER, Julia , GNOTH, Mark, Jean , LANG, Dieter
IPC分类号： C07D413/14 , A61K31/4439 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel, substituted oxazolidinones, methods for the production thereof, use thereof for the treatment and/or prophylaxis of diseases, and the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
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公开(公告)号：EP3105209B1
公开(公告)日：2019-08-21
申请号：EP15703288.9
申请日：2015-02-10
发明人： REHWINKEL, Hartmut , PANKNIN, Olaf , RING, Sven , ANLAUF, Sonja , SIEBENEICHER, Holger , NGUYEN, Duy , SCHWEDE, Wolfgang , BAUSER, Marcus , ZIMMERMANN, Katja , KAULFUSS, Stefan , NEUHAUS, Roland , BLANEY, Paul, Matthew
IPC分类号： C07D235/30 , A61K31/4184 , A61P35/00
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公开(公告)号：EP3105210B1
公开(公告)日：2019-01-30
申请号：EP15705936.1
申请日：2015-02-10
发明人： REHWINKEL, Hartmut , SIEBENEICHER, Holger , ANLAUF, Sonja , NGUYEN, Duy , PANKNIN, Olaf , RING, Sven , SCHWEDE, Wolfgang , BAUSER, Marcus , ZIMMERMANN, Katja , KAULFUSS, Stefan , NEUHAUS, Roland , PUSCH, Stefan , VON DEIMLING, Andreas
IPC分类号： C07D235/30 , A61K31/4184 , A61P35/00
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5.发明授权SUBSTITUIERTE (OXAZOLIDINON-5-YL-METHYL) -2-THIOPHEN-CARBOXAMIDE UND IHRE VERWENDUNG IM GEBIET DER BLUTGERINNUNG 有权取代的（恶唑烷酮-5-基 - 甲基）-2-噻吩甲酰胺和它们在血液凝固领域
公开(公告)号：EP2173744B1
公开(公告)日：2011-10-05
申请号：EP08759099.8
申请日：2008-06-07
发明人： ALLERHEILIGEN, Swen , BAUSER, Marcus , SCHIROK, Hartmut , RESTER, Ulrich , HEITMEIER, Stefan , GERDES, Christoph , VON DEGENFELD, Georges , DITTRICH-WENGENROTH, Elke , SAATMANN, Uwe , STRASSBURGER, Julia , MÜNTER, Klaus , GNOTH, Mark, Jean , LANG, Dieter
IPC分类号： C07D413/14 , A61K31/4439 , A61P7/00
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, methods for the production thereof, use thereof for treating and/or for the prophylaxis of diseases and use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular thromboembolic disorders.
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公开(公告)号：EP3105209A1
公开(公告)日：2016-12-21
申请号：EP15703288.9
申请日：2015-02-10
发明人： REHWINKEL, Hartmut , PANKNIN, Olaf , RING, Sven , ANLAUF, Sonja , SIEBENEICHER, Holger , NGUYEN, Duy , SCHWEDE, Wolfgang , BAUSER, Marcus , ZIMMERMANN, Katja , KAULFUSS, Stefan , NEUHAUS, Roland , BLANEY, Paul, Matthew
IPC分类号： C07D235/30 , A61K31/4184 , A61P35/00
CPC分类号： C07D235/30 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/12
摘要： The present invention relates to benzimidazol-2-amines of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
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7.发明公开1-CYCLOHEXYL-2-PHENYLAMINOBENZIMIDAZOLES AS MIDH1 INHIBITORS FOR THE TREATMENT OF TUMORS 审中-公开1-环己基-2-苯基氨基苯并咪唑作为MIDH1抑制剂治疗肿瘤
公开(公告)号：EP3209660A1
公开(公告)日：2017-08-30
申请号：EP15784037.2
申请日：2015-10-21
发明人： REHWINKEL, Hartmut , ANLAUF, Sonja , NGUYEN, Duy , PANKNIN, Olaf , BAUSER, Marcus , ZIMMERMANN, Katja , KAULFUSS, Stefan , NEUHAUS, Roland , BLANEY, Paul Matthew , TOSCHI, Gianna
IPC分类号： C07D413/04 , C07D235/30 , C07D403/04 , C07D401/04 , A61K31/422 , A61P35/00
CPC分类号： A61K31/4184 , C07D235/30 , C07D401/04 , C07D403/04 , C07D413/04
摘要： The present invention relates to benzimidazol-2-amines of general formula (I) in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的苯并咪唑-2-胺，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所定义， 所述化合物，用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及所述化合物在制备用于治疗或预防疾病，特别是肿瘤作为唯一药物的药物组合物中的用途 或与其他活性成分组合。
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公开(公告)号：EP3209646A1
公开(公告)日：2017-08-30
申请号：EP15781679.4
申请日：2015-10-20
IPC分类号： C07D235/30 , A61K31/4184 , A61P35/00
摘要： The present invention relates to benzimidazol-2-amines of general formula (I) in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的苯并咪唑-2-胺，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所定义， 所述化合物，用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及所述化合物在制备用于治疗或预防疾病，特别是肿瘤作为唯一药物的药物组合物中的用途 或与其他活性成分组合。
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公开(公告)号：EP3105210A1
公开(公告)日：2016-12-21
申请号：EP15705936.1
申请日：2015-02-10
发明人： REHWINKEL, Hartmut , SIEBENEICHER, Holger , ANLAUF, Sonja , NGUYEN, Duy , PANKNIN, Olaf , RING, Sven , SCHWEDE, Wolfgang , BAUSER, Marcus , ZIMMERMANN, Katja , KAULFUSS, Stefan , NEUHAUS, Roland
IPC分类号： C07D235/30 , A61K31/4184 , A61P35/00
CPC分类号： C07D235/30 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to benzimidazol-2-amines of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的苯并咪唑-2-胺：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本文所定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及所述化合物在制备用于治疗或预防的药物组合物中的用途 疾病，特别是肿瘤，作为单一药剂或与其他活性成分组合。
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