- 专利标题: TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY
-
申请号: EP15755646申请日: 2015-02-27
-
公开(公告)号: EP3110824A4公开(公告)日: 2017-11-29
- 发明人: TREMBLAY MICHEL L , PENAFUERTE CLAUDIA , FELDHAMMER MATTHEW , ZOGOPOULOS GEORGE , BLACK CAMERON , CRANE SHELDON , TRUONG VOUY-LINH , KENNEDY BRIAN
- 申请人: THE ROYAL INST FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV
- 专利权人: THE ROYAL INST FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV
- 当前专利权人: THE ROYAL INST FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV
- 优先权: US201461945922 2014-02-28
- 主分类号: C07F9/6553
- IPC分类号: C07F9/6553 ; A61K31/662 ; A61K31/67 ; A61K35/15 ; A61P31/00 ; A61P31/18 ; A61P33/00 ; A61P35/00 ; A61P37/02 ; C12N5/078 ; C12N9/16
摘要:
The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.
信息查询