公开(公告)号：EP3110824A4

公开(公告)日：2017-11-29

申请号：EP15755646

申请日：2015-02-27

申请人： THE ROYAL INST FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV

发明人： TREMBLAY MICHEL L ,  PENAFUERTE CLAUDIA ,  FELDHAMMER MATTHEW ,  ZOGOPOULOS GEORGE ,  BLACK CAMERON ,  CRANE SHELDON ,  TRUONG VOUY-LINH ,  KENNEDY BRIAN

IPC分类号： C07F9/6553 ,  A61K31/662 ,  A61K31/67 ,  A61K35/15 ,  A61P31/00 ,  A61P31/18 ,  A61P33/00 ,  A61P35/00 ,  A61P37/02 ,  C12N5/078 ,  C12N9/16

CPC分类号： C07F9/655354 ,  A61K31/662 ,  A61K31/67 ,  A61K35/15 ,  A61K39/0011 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/5154 ,  C12N9/16 ,  A61K2300/00

摘要： The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.