发明公开
EP3200822A1 BINDING MOLECULES, ESPECIALLY ANTIBODIES, BINDING TO L1CAM (CD171)
审中-公开
结合分子,特别是抗体,结合L1CAM(CD171)
- 专利标题: BINDING MOLECULES, ESPECIALLY ANTIBODIES, BINDING TO L1CAM (CD171)
- 专利标题(中): 结合分子,特别是抗体,结合L1CAM(CD171)
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申请号: EP15770889.2申请日: 2015-09-28
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公开(公告)号: EP3200822A1公开(公告)日: 2017-08-09
- 发明人: ALTEVOGT, Peter , LÜTTGAU, Sandra , MOLDENHAUER, Gerhard , HAZIN, John
- 申请人: Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts
- 申请人地址: Im Neuenheimer Feld 280 69120 Heidelberg DE
- 专利权人: Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts
- 当前专利权人: Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts
- 当前专利权人地址: Im Neuenheimer Feld 280 69120 Heidelberg DE
- 代理机构: Lahrtz, Fritz
- 优先权: EP14003383 20140930
- 国际公布: WO2016050702 20160407
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/28 ; A61P35/00 ; A61K39/00
摘要:
The present disclosure relates to a binding molecule binding to L1, which is capable of binding to the same L1 epitope recognized by the monoclonal antibody L1-OV52.24, and/or which competes with the monoclonal antibody L1-OV52.24 for binding to L1, wherein the variable part of the light chain of L1-OV52.24 comprises the sequence according to SEQ ID No: 1 or wherein the light chain is encoded by SEQ ID No: 3, and wherein the variable part of the heavy chain of L1-OV52.24 comprises the sequence according to SEQ ID No: 2 or wherein the heavy chain is encoded by SEQ ID No: 4, nucleic acids encoding the binding molecules, uses thereof and pharmaceutical compositions comprising the binding molecules.
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