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公开(公告)号：EP1608679A1
公开(公告)日：2005-12-28
申请号：EP04725368.7
申请日：2004-04-02
申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts , Ruprecht-Karls-Universität Heidelberg
发明人： PONSTINGL, Herwig , ZIMMERMANN, Hans-Peter , MOLDENHAUER, Gerhard , MARM , Alexander , Bastert, Gunther , Kurek, Raffael , Wallwiener, Diethelm
IPC分类号： C07K14/435 , C12N15/12 , C12N15/63 , C12N15/74 , C12N15/79 , A01K67/027 , A61K38/17 , A61K48/00 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/4708 , A01K2217/05 , C07K2319/60
摘要： Described is a novel marker protein associated with epithelial tumors, e.g., ovarian, mammary, stomach, kidney, thyroid and lung carcinomas, Dropl, a dystrophin-related protein as well as a nucleic acid molecule encoding Dropl. Furthermore, various diagnostic and therapeutic uses based on the finding that the expression of Dropl is downregulated in epithelial tumors are described.
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公开(公告)号：EP2170956A2
公开(公告)日：2010-04-07
申请号：EP08759230.9
申请日：2008-06-13
发明人： GAST, Daniela , ALTEVOGT, Peter , MOLDENHAUER, Gerhard , BREITLING, Frank , KRÜGER, Achim , WOLTERINK, Silke , LÜTTGAU, Sandra , MÖBIUS, Ulrich , LI, Yi
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
摘要： The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.
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公开(公告)号：EP2170956B1
公开(公告)日：2014-10-22
申请号：EP08759230.9
申请日：2008-06-13
发明人： KELM, Daniela , ALTEVOGT, Peter , MOLDENHAUER, Gerhard , BREITLING, Frank , KRÜGER, Achim , BÄRREITER, Silke , LÜTTGAU, Sandra , MÖBIUS, Ulrich , LI, Yi , SEBENS, Susanne , SCHÄFER, Heiner
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
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4.发明公开
公开(公告)号：EP3200822A1
公开(公告)日：2017-08-09
申请号：EP15770889.2
申请日：2015-09-28
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00 , A61K39/00
CPC分类号： C07K16/2803 , A61K31/277 , A61K31/337 , A61K31/365 , A61K31/407 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/15 , A61K39/39558 , A61K45/06 , A61K47/48561 , A61K2039/505 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492
摘要： The present disclosure relates to a binding molecule binding to L1, which is capable of binding to the same L1 epitope recognized by the monoclonal antibody L1-OV52.24, and/or which competes with the monoclonal antibody L1-OV52.24 for binding to L1, wherein the variable part of the light chain of L1-OV52.24 comprises the sequence according to SEQ ID No: 1 or wherein the light chain is encoded by SEQ ID No: 3, and wherein the variable part of the heavy chain of L1-OV52.24 comprises the sequence according to SEQ ID No: 2 or wherein the heavy chain is encoded by SEQ ID No: 4, nucleic acids encoding the binding molecules, uses thereof and pharmaceutical compositions comprising the binding molecules.
摘要翻译： 本公开涉及与L1结合的结合分子，其能够与单克隆抗体L1-OV52.24识别的相同L1表位结合，和/或与单克隆抗体L1-OV52.24竞争结合 L1，其中L1-OV52.24的轻链的可变部分包含根据SEQ ID No：1的序列或其中轻链由SEQ ID No：3编码，并且其中重链的可变部分 L1-OV52.24包含根据SEQ ID No：2的序列或其中重链由SEQ ID No：4编码，编码结合分子的核酸，其用途和包含结合分子的药物组合物。
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公开(公告)号：EP0983302B1
公开(公告)日：2006-04-26
申请号：EP98934774.5
申请日：1998-05-22
IPC分类号： C07K16/28 , A61K39/395 , G01N33/577 , G01N33/574
CPC分类号： C07K16/2809
摘要： The invention relates to an H100A position point-mutated OKT3 antibody, and to a method for the production and use thereof.
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