发明公开
- 专利标题： CHECKPOINT BLOCKADE AND MICROSATELLITE INSTABILITY
- 专利标题（中）： 检查点堵塞和微粒不稳定性
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申请号： EP15858277.5申请日： 2015-11-12
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公开(公告)号： EP3218004A1公开(公告)日： 2017-09-20
- 发明人: DIAZ, Luis , VOGELSTEIN, Bert , KINZLER, Kenneth W. , PAPADOPOULOS, Nickolas , LE, Dung
- 申请人： The Johns Hopkins University
- 申请人地址： 3400 North Charles Street Baltimore, MD 21218 US
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 当前专利权人地址： 3400 North Charles Street Baltimore, MD 21218 US
- 代理机构： Tombling, Adrian George
- 优先权： US201462079357P 20141113; US201562190977P 20150710
- 国际公布： WO2016077553 20160519
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P35/00
摘要：
Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.
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