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公开(公告)号:EP2934576A1
公开(公告)日:2015-10-28
申请号:EP13818155.7
申请日:2013-12-19
CPC分类号: C07K16/2827 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要: Anti-human B7-H4 antibody "6H3", antigen-binding fragments, derivatives, and humanized variants thereof that are capable of immunospecifically binding to B7-H4, and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases are disclosed. In preferred embodiments, the molecules are used to retard or prevent tumor growth, inhibit tumor- mediated suppression, eliminate tumors and/or deplete or block the activity of tumor-associated macrophages ("TAMs") so as to alter their activity and/or decrease TAM-mediated immune suppression.
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公开(公告)号:EP4441702A1
公开(公告)日:2024-10-09
申请号:EP22826528.6
申请日:2022-11-18
发明人: HELM, Patrick A. , SIEWERDSEN, Jeffrey H. , UNERI, Ali , JONES, Craig K. , HUANG, Yixuan , ZHANG, Xiaoxuan
CPC分类号: G06T2207/3001220130101 , G06T7/0002 , G06T7/174 , G06T2207/2008120130101 , G06T2207/1011620130101 , G06T2207/2008420130101 , G06T2207/2001620130101 , A61B6/4078 , A61B6/4085 , A61B6/4035 , A61B6/06 , A61B6/505 , A61B6/12 , A61B6/5235 , A61B6/5241 , A61B6/5205 , A61B6/5223
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公开(公告)号:EP4441693A1
公开(公告)日:2024-10-09
申请号:EP22834796.9
申请日:2022-11-18
发明人: HELM, Patrick A. , SIEWERDSEN, Jeffrey H. , UNERI, Ali , JONES, Craig K. , HUANG, Yixuan , ZHANG, Xiaoxuan
CPC分类号: G06T7/344 , G06T7/32 , G06T2207/1008120130101 , G06T2207/1011620130101 , G06T2207/3001220130101 , A61B6/03 , A61B6/4405 , A61B6/5217 , A61B6/12 , A61B6/505 , A61B6/5241 , A61B6/5235 , A61B6/5247 , A61B6/4035 , A61B6/482 , G06T3/14
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公开(公告)号:EP4440433A1
公开(公告)日:2024-10-09
申请号:EP22902115.9
申请日:2022-11-30
IPC分类号: A61B5/24 , A61B5/0205 , A61B5/103
CPC分类号: A61B5/0205 , A61B5/14542 , A61B5/021 , A61B5/14532 , A61B5/0533 , A61B5/163 , A61B5/681 , A61B5/6803 , A61B5/4094 , A61B5/02416 , A61B2562/021920130101 , A61B5/7267 , A61B5/746 , A61B5/0022
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公开(公告)号:EP4427043A1
公开(公告)日:2024-09-11
申请号:EP22890642.6
申请日:2022-10-31
发明人: FAVA, Andrea , PETRI, Michelle
IPC分类号: G01N33/564
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公开(公告)号:EP4404953A1
公开(公告)日:2024-07-31
申请号:EP22873808.4
申请日:2022-09-20
发明人: COLLER, Jeffery
IPC分类号: A61K38/46 , A61K48/00 , C07K14/195 , C12N5/10 , C12N15/55
CPC分类号: C12N9/22 , C07K2319/8520130101 , C07K2319/0020130101 , C12N9/1029 , C12N2310/2020170501 , C07K2319/09520130101 , A61K38/00
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公开(公告)号:EP3427736B1
公开(公告)日:2024-06-19
申请号:EP18192915.9
申请日:2008-06-19
IPC分类号: A61K31/4706 , C07D215/54 , C07D215/16 , C07D215/42 , C07D215/48 , A61P9/10 , A61P25/00 , A61P29/00 , A61P35/00 , C07D215/46
CPC分类号: A61P9/10 , A61P25/00 , A61P29/00 , A61P35/00 , C07D215/16 , C07D215/46 , C07D215/42 , A61K31/4706 , C07D215/48 , C07D215/54
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公开(公告)号:EP3964502B1
公开(公告)日:2024-06-12
申请号:EP21198449.7
申请日:2010-03-19
IPC分类号: C07D257/00 , A61K31/41 , A61K49/00 , A61P35/00
CPC分类号: C07D209/14 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/82 , C07D257/02 , C07D209/12 , C07D311/20 , A61P35/00
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9.
公开(公告)号:EP4373839A1
公开(公告)日:2024-05-29
申请号:EP22846765.0
申请日:2022-07-18
发明人: CUI, Honggang , LI, Yi , STERN, David , XU, XuanKuo , LOCK, Lye, Lin , MILLS, Jason , GHOSE, Sanchayita , LI, Zheng Jian
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公开(公告)号:EP3465457B1
公开(公告)日:2023-10-25
申请号:EP17807649.3
申请日:2017-06-05
发明人: TRAN, Cao-Ly , RAUM, Dwight , SCOTT, John, W. , SPANGLER, Joshua, G. , BYSTRY, Kelly, L. , SMITH, Kirby, S. , AMICK, Marc, A. , GIANUZZI, Philip, J. , SCHMITT, Charles, E.
IPC分类号: H04L51/066
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