发明公开
- 专利标题： FUROXAN COMPOUND, AND MANUFACTURING METHOD FOR SAME
- 专利标题（中）： 呋喃酮化合物及其制造方法
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申请号： EP15877758.1申请日： 2015-12-15
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公开(公告)号： EP3246322A1公开(公告)日： 2017-11-22
- 发明人: MATSUBARA, Ryosuke , ANDO, Akihiro , HAYASHI, Masahiko
- 申请人： National University Corporation Kobe University
- 申请人地址： 1-1 Rokkodai-cho Nada-ku Kobe-shi, Hyogo 657-8501 JP
- 专利权人： National University Corporation Kobe University
- 当前专利权人： National University Corporation Kobe University
- 当前专利权人地址： 1-1 Rokkodai-cho Nada-ku Kobe-shi, Hyogo 657-8501 JP
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： JP2015004700 20150114
- 国际公布： WO2016113802 20160721
- 主分类号： C07D271/08
- IPC分类号： C07D271/08 ; A61K31/4245 ; A61P9/10 ; A61P25/08 ; A61P25/28 ; A61P35/00
摘要：
The present invention provides: a furoxan compound having a fluorine atom as a substituent group on the ring structure thereof; and a novel nitric oxide donor including the compound. The present invention relates to a fluorofuroxan compound represented by general formula (1) or (2). The compound of formula (1) can be manufactured by reacting a fluoride salt with a nitrofuroxan compound to substitute the nitro group with a fluoro group. The compound of formula (2) can be manufactured by subjecting the compounds of formula (1) to isomerization by irradiation with light.
公开/授权文献
- EP3246322B1 FUROXAN COMPOUND, AND MANUFACTURING METHOD FOR SAME 公开/授权日：2021-01-27
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