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公开(公告)号：EP4428171A1
公开(公告)日：2024-09-11
申请号：EP22889869.8
申请日：2022-10-27
发明人： TSUDA, Akihiko , OKAZOE, Takashi , WADA, Hiroshi , TANAKA, Hideaki , SUNAYAMA, Yoshitaka , KAKIUCHI, Toshifumi
IPC分类号： C08G18/80 , C07C271/20 , C08G71/04
CPC分类号： C08G71/04 , C07C271/20 , C08G18/80
摘要： The objective of the present invention is to provide a method for producing a high quality fluorine-containing polyurethane without using an isocyanate, and a fluorine-containing biscarbamate compound used for the method. The method for producing a fluorine-containing polyurethane according to the present invention is characterized in comprising the step of reacting a fluorine-containing biscarbamate compound represented by the following formula (I) and a diol compound represented by the following formula (II), wherein the fluorine-containing polyurethane is represented by the following formula (III):
wherein Rf1 is a fluorine-containing C1-6 alkyl group, Rf2 is a divalent fluorine-containing organic group, R1 is a divalent organic group.-
2.发明公开
公开(公告)号：EP4394383A1
公开(公告)日：2024-07-03
申请号：EP22861472.3
申请日：2022-08-26
IPC分类号： G01N33/543
CPC分类号： G01N33/543
摘要： There are provided a sensor for analysis that can easily and sensitively perform analysis and inspection, a substrate for producing a sensor for analysis, a particle used for producing the substrate, and related technologies. The present disclosure provides a particle including a particle core and a modifier integrated with the particle core by an intermolecular chemical bonding that is separable under conditions that do not damage the particle core, or a particle for producing a substrate for producing a sensor for analysis, in which the particle includes a particle core and a modifier integrated with the core by an intermolecular chemical bonding that is separable under conditions that do not damage the substrate.
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公开(公告)号：EP3348638B1
公开(公告)日：2022-12-14
申请号：EP16844517.9
申请日：2016-09-09
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公开(公告)号：EP3382385B1
公开(公告)日：2022-02-16
申请号：EP16866326.8
申请日：2016-11-15
发明人： KIMURA Kenjiro , KIMURA Noriaki
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公开(公告)号：EP3409343B1
公开(公告)日：2021-04-28
申请号：EP17744063.3
申请日：2017-01-19
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公开(公告)号：EP3246322B1
公开(公告)日：2021-01-27
申请号：EP15877758.1
申请日：2015-12-15
IPC分类号： C07D271/08 , A61K31/4245 , A61P9/10 , A61P25/08 , A61P25/28 , A61P35/00
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公开(公告)号：EP3739047A1
公开(公告)日：2020-11-18
申请号：EP20168727.4
申请日：2015-11-02
发明人： NISHIDA, Keiji , KONDO, Akihiko
摘要： The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and DNA glycosylase with sufficiently low reactivity with a DNA having an unrelaxed double helix structure (unrelaxed DNA) are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.
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8.发明公开
公开(公告)号：EP3715454A1
公开(公告)日：2020-09-30
申请号：EP18882051.8
申请日：2018-11-21
发明人： NISHIDA, Keiji
摘要： The present invention provides a complex containing a nucleic acid sequence-recognizing module and a proteolysis tag, wherein the module is linked to the proteolysis tag, the module specifically binds to a target nucleotide sequence in a double stranded DNA, and the tag consists of (i) a peptide containing 3 hydrophobic amino acid residues at the C-terminal, or (ii) a peptide containing 3 amino acid residues at the C-terminal wherein at least a part of the amino acid residues is substituted by serine.
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公开(公告)号：EP3660152A1
公开(公告)日：2020-06-03
申请号：EP19776369.1
申请日：2019-03-26
发明人： NISHIDA, Keiji
IPC分类号： C12N15/09
摘要： The present invention provides a method for modifying a targeted site of a double-stranded DNA in a cell, the method including a step of bringing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a selected target nucleotide sequence in a double-stranded DNA and a nucleic acid base converting enzyme or DNA glycosylase are linked, and a donor DNA containing an insertion sequence into contact with said double-stranded DNA, to substitute the targeted site with the insertion sequence, or insert the insertion sequence into said targeted site, without cleaving at least one strand of said double-stranded DNA in the targeted site.
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公开(公告)号：EP3636186A1
公开(公告)日：2020-04-15
申请号：EP18814248.3
申请日：2018-05-30
发明人： KAKUTANI, Kenichiro
IPC分类号： A61B17/70
摘要： The purpose of the present invention is to provide a spinal fusion implant capable of preserving turning properties of vertebral bodies, and in addition, capable of preventing false screwing (false insertion) of screws. Connection plates 3 constituting a spinal fusion implant 101 each have, on a ventral-side surface 3b, a convex-shaped portion 8 that is fitted into a concave-shaped portion of an intervertebral joint 53. In addition, a center hole 3d through which a center rod 4 is slidably inserted is formed on a side surface of the connection plate 3, such that the center of the hole is positioned closer to the back side than a virtual line L1 connecting midpoints on arc-shaped contour lines C of the concave-shaped portions of the adjacent intervertebral joints 53 when viewed from the head side of a human body.
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