发明公开
- 专利标题： BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
- 专利标题（中）： 可生物降解的脂质用于递送活性剂
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申请号： EP17000656.3申请日： 2011-06-03
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公开(公告)号： EP3254672A1公开(公告)日： 2017-12-13
- 发明人: Manoharan, Muthiah , Maier, Martin , Jayaraman, Muthusamy , Matsuda, Shigeo , Jayaprakash, Narayanannair, K. , Rajeev, Kallanthottathil, G. , Akinc, Akin , Baillie, Thomas, A.
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： 300 Third Street Cambridge, MA 02142 US
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： 300 Third Street Cambridge, MA 02142 US
- 代理机构： Müller-Boré & Partner Patentanwälte PartG mbB
- 优先权： US351146P 20100603; US201161489197P 20110523
- 主分类号： A61K9/10
- IPC分类号： A61K9/10 ; A61K39/00 ; A61K48/00 ; C07C69/02 ; C07C211/62 ; C07C211/63 ; C12N15/87 ; A61K31/713 ; A61K47/44 ; C07C229/12 ; C12N15/113 ; C12N15/88
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
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