发明公开
- 专利标题： PYRIMIDINES AS SODIUM CHANNEL BLOCKERS
- 专利标题（中）： 嘧啶作为钠通道阻断剂
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申请号： EP17179551.1申请日： 2012-08-31
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公开(公告)号： EP3255041A1公开(公告)日： 2017-12-13
- 发明人: NI, Chiyou , PARK, Minnie , SHAO, Bin , TAFESSE, Laykea , YAO, Jiangchao , YOUNGMAN, Mark
- 申请人： Purdue Pharma L.P.
- 申请人地址： One Stamford Forum 201 Tresser Boulevard Stamford, CT 06901 US
- 专利权人： Purdue Pharma L.P.
- 当前专利权人： Purdue Pharma L.P.
- 当前专利权人地址： One Stamford Forum 201 Tresser Boulevard Stamford, CT 06901 US
- 代理机构： Maiwald Patentanwalts GmbH
- 优先权： US201161530678P 20110902; US201261651611P 20120525
- 主分类号： C07D233/90
- IPC分类号： C07D233/90 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D403/12 ; C07D405/12 ; C07D405/14 ; A61K31/4418 ; A61P25/08
摘要：
The present disclosure provides substituted pyrimidine compounds of Formula I:
and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A 1 , X, A 2 , W 1 , W 2 , W 3 , E, Z, and R 4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A 1 , X, A 2 , W 1 , W 2 , W 3 , E, Z, and R 4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
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