发明公开
- 专利标题： AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES
- 专利标题（中）： 具有神经保护性质的两性化合物
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申请号： EP17183215.7申请日： 2015-08-25
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公开(公告)号： EP3260462A1公开(公告)日： 2017-12-27
- 发明人: Kudova, Eva , Chodounska, Hana , Kapras, Vojtech , Vyklicky, Ladislav , Vales, Karel , Jahn, Ullrich
- 申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. , Fyziologicky Ustav AV CR, v.v.i.
- 申请人地址： Flemingovo nam. 542/2 166 10 Praha 6 CZ
- 专利权人： Ustav organicke chemie a biochemie AV CR, v.v.i.,Fyziologicky Ustav AV CR, v.v.i.
- 当前专利权人： Ustav organicke chemie a biochemie AV CR, v.v.i.,Fyziologicky Ustav AV CR, v.v.i.
- 当前专利权人地址： Flemingovo nam. 542/2 166 10 Praha 6 CZ
- 代理机构： Hartvichova, Katerina
- 优先权： CZ201400575U 20140826
- 主分类号： C07J1/00
- IPC分类号： C07J1/00 ; C07J9/00 ; C07J13/00 ; C07J31/00 ; C07J41/00 ; C07J43/00 ; C07J63/00 ; C07J71/00 ; A61K31/56 ; A61P25/00 ; A61P25/08 ; A61P25/28 ; A61P25/24 ; A61P25/22 ; A61P25/18 ; A61P25/30 ; C07C279/14 ; C07C305/20 ; C07C211/63 ; C07C13/60 ; C07C55/00
摘要：
The present invention provides amphiphilic compounds with a tetradecahydrophenanthrene skeleton of formula (I), wherein R1-R5 are as defined herein, and their enantiomers, exhibiting neuroprotective effects, for use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain , addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.
公开/授权文献
- EP3260462B1 AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES 公开/授权日：2019-04-17
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