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公开(公告)号：EP3947410A1
公开(公告)日：2022-02-09
申请号：EP20718527.3
申请日：2020-04-02
发明人： KUDOVA, Eva , CHODOUNSKA, Hana , MARES, Pavel , VALES, Karel
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公开(公告)号：EP3280722B8
公开(公告)日：2019-06-26
申请号：EP16721001.2
申请日：2016-04-08
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公开(公告)号：EP3354269A1
公开(公告)日：2018-08-01
申请号：EP18153496.7
申请日：2018-01-25
IPC分类号： A61K31/765 , A61K8/86 , A61K36/00 , A23L29/206 , A23L33/00 , A61P3/06 , A61P3/04 , A61P3/08 , A61P3/10
CPC分类号： A61K31/765 , A23L29/206 , A23L33/00 , A23L33/22 , A23L33/30 , A61K36/00 , A61K2236/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10
摘要： The present invention relates to a preparation for oral administration containing lignin for use in the prevention and/or treatment of obesity and/or obesity-induced metabolic complications (abdominal fat accumulation, glucose intolerance, hepatic steatosis) in humans suffering from obesity. It further relates to the use of the preparation containing lignin as a food supplement to reduce overweight and/or to improve the overweight-induced metabolic complications in overweight individuals.
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公开(公告)号：EP3186267A1
公开(公告)日：2017-07-05
申请号：EP15763482.5
申请日：2015-08-25
发明人： KUDOVA, Eva , CHODOUNSKA, Hana , KAPRAS, Vojtech , VYKLICKY, Ladislav , VALES, Karel , JAHN, Ullrich
IPC分类号： C07J1/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J63/00 , C07J71/00 , A61K31/56 , A61P25/00 , A61P25/08 , A61P25/28 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/30 , C07C279/14 , C07C305/20 , C07C211/63 , C07C13/60 , C07C55/00
CPC分类号： C07J43/003 , C07C59/80 , C07C305/20 , C07C2603/26 , C07D209/36 , C07D213/18 , C07D317/72 , C07J1/0007 , C07J1/0011 , C07J9/00 , C07J9/005 , C07J13/007 , C07J31/006 , C07J41/0005 , C07J41/0033 , C07J41/0038 , C07J53/001 , C07J63/008 , C07J71/0005
摘要： The present invention provides amphiphilic compounds with a tetradecahydrophenanthrene skeleton of formula (I), wherein R1-R5 are as defined herein, and their enantiomers, exhibiting neuroprotective effects, for use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain , addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.
摘要翻译： 本发明提供了具有十四氢菲构架的两亲化合物及其对映异构体，表现出神经保护作用，其作为药物用于治疗与谷氨酸能神经递质系统失衡相关的神经精神病症，例如CNS的缺血性损伤，CNS的神经退行性改变和病症，情感障碍 ，抑郁症，创伤后应激障碍以及与压力，焦虑，精神分裂症和精神障碍有关的疾病，疼痛，成瘾，多发性硬化症，癫痫症，神经胶质瘤和含有所述化合物的药物组合物。
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公开(公告)号：EP3186267B1
公开(公告)日：2019-10-02
申请号：EP15763482.5
申请日：2015-08-25
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公开(公告)号：EP3260462A1
公开(公告)日：2017-12-27
申请号：EP17183215.7
申请日：2015-08-25
发明人： Kudova, Eva , Chodounska, Hana , Kapras, Vojtech , Vyklicky, Ladislav , Vales, Karel , Jahn, Ullrich
IPC分类号： C07J1/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J63/00 , C07J71/00 , A61K31/56 , A61P25/00 , A61P25/08 , A61P25/28 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/30 , C07C279/14 , C07C305/20 , C07C211/63 , C07C13/60 , C07C55/00
CPC分类号： C07J43/003 , C07C59/80 , C07C305/20 , C07C2603/26 , C07D209/36 , C07D213/18 , C07D317/72 , C07J1/0007 , C07J1/0011 , C07J9/00 , C07J9/005 , C07J13/007 , C07J31/006 , C07J41/0005 , C07J41/0033 , C07J41/0038 , C07J53/001 , C07J63/008 , C07J71/0005
摘要： The present invention provides amphiphilic compounds with a tetradecahydrophenanthrene skeleton of formula (I), wherein R1-R5 are as defined herein, and their enantiomers, exhibiting neuroprotective effects, for use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain , addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.
摘要翻译： 本发明提供了具有式（I）的十四氢菲构架的两亲化合物，其中R1-R5如本文所定义，并且它们的对映异构体具有神经保护作用，用作治疗与谷氨酸能神经递质系统失衡有关的神经精神病症的药物， 如中枢神经系统的缺血性损伤，神经退行性改变和中枢神经系统病症，情感障碍，抑郁症，创伤后应激障碍以及与压力，焦虑，精神分裂症和精神障碍有关的疾病，疼痛，成瘾，多发性硬化症，癫痫症，神经胶质瘤和 含有该化合物的药物组合物
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7.发明公开
公开(公告)号：EP4072555A1
公开(公告)日：2022-10-19
申请号：EP20828753.2
申请日：2020-12-08
IPC分类号： A61K31/506 , A61K31/4045 , A61K31/403 , A61K31/18 , A61K31/4439 , A61K31/437 , A61K31/337 , A61K31/4745 , A61K31/475 , A61K31/4025 , A61K45/06
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公开(公告)号：EP3716957A1
公开(公告)日：2020-10-07
申请号：EP18829194.2
申请日：2018-11-26
发明人： KUDOVA, Eva , VYKLICKY, Ladislav
IPC分类号： A61K31/00 , A61K31/56 , A61K31/568 , A61K31/57 , A61P25/28
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公开(公告)号：EP3260462B1
公开(公告)日：2019-04-17
申请号：EP17183215.7
申请日：2015-08-25
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