- 专利标题： ANTIMICROBIAL PEPTIDES AND THEIR USE FOR THE TREATMENT OF TOPICAL INFECTIONS
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申请号： EP16721001.2申请日： 2016-04-08
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公开(公告)号： EP3280722B1公开(公告)日： 2019-05-15
- 发明人: CEROVSKY, Vaclav , NESUTA, Ondrej , DUDKOVA, Vlasta , SYCHROVA, Hana , KODEDOVA, Marie
- 申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. , Biotechnologicky Ustav AV CR, v.v.i.
- 申请人地址： Flemingovo nam. 2 166 10 Praha 6 CZ
- 专利权人： Ustav organicke chemie a biochemie AV CR, v.v.i.,Biotechnologicky Ustav AV CR, v.v.i.
- 当前专利权人： Ustav organicke chemie a biochemie AV CR, v.v.i.,Biotechnologicky Ustav AV CR, v.v.i.
- 当前专利权人地址： Flemingovo nam. 2 166 10 Praha 6 CZ
- 代理机构： Hartvichova, Katerina
- 优先权： CZ20150244 20150410
- 国际公布： WO2016161997 20161013
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; A61K38/04
摘要：
Synthetic analogs of general formula (I-A), 5 a-Ile-b-c-d-e-f-Lys-Lys-g-h-i-j-Ile-k-Lys-NH2 (I-A) where a is Gly, Lys or β-Ala; b is Met, Leu, Nle, Ile, Trp, Val or Phe; c is Ser, Lys, Arg or Orn; d is Ser, Lys, Arg or Orn; e is Leu, Nle, Ile, Trp, Val or Phe; f is Met, Leu, Nle, Ile, Trp, Val or Phe; g is Leu, Nle, Ile orTrp; h is Lys, Arg, Orn or Ala; i is Lys, Arg, Orn or Ala; j is Ile, Leu, Nle or His; k is Lys, Arg, Orn or Ala; where amino acids in all positions may be in D-configuration, and their use for the treatment of topical infections caused by pathogenic bacteria or yeasts.
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